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  1. Article

    Open Access

    Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis

    Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous ...

    Samuel C. Forster, Simon Clare, Benjamin S. Beresford-Jones… in Nature Microbiology (2022)

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    Article

    High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation

    By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...

    Lucie Abeler-Dörner, Adam G. Laing, Anna Lorenc, Dmitry S. Ushakov… in Nature Immunology (2020)

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    Article

    C13orf31 (FAMIN) is a central regulator of immunometabolic function

    Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation a...

    M Zaeem Cader, Katharina Boroviak, Qifeng Zhang, Ghazaleh Assadi… in Nature Immunology (2016)

  4. No Access

    Article

    Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host

    Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host specie...

    Elizabeth J. Klemm, Effrossyni Gkrania-Klotsas, James Hadfield… in Nature Microbiology (2016)