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A community effort to create standards for evaluating tumor subclonal reconstruction

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  1. Article

    Open Access

    Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

    The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-geno...

    Anna Y. Lee, Adam D. Ewing, Kyle Ellrott, Yin Hu, Kathleen E. Houlahan… in Genome Biology (2018)

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  2. Article

    Open Access

    Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

    Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of develo** prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, h...

    Renea A. Taylor, Michael Fraser, Julie Livingstone… in Nature Communications (2017)

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