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Article
Open AccessCombining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection
The phenotypes of cancer cells are driven in part by somatic structural variants. Structural variants can initiate tumors, enhance their aggressiveness, and provide unique therapeutic opportunities. Whole-geno...
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Article
Open AccessGermline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of develo** prostate cancer (PCa) and increased risk of aggressive disease. To understand this aggression, h...