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Article
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
The sialic acid–dependent interaction of the co-inhibitory receptors CD24 and SiglecG prevents excessive inflammatory responses to pathogen infection. Chen et al. show that microbial sialidases exacerbate sepsis ...
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Article
Erratum: Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
Nat. Biotechnol. 29, 428–435 (2011); published online 6 May 2011; corrected after print 18 January 2012 In the version of this article initially published, a line in the abstract read, “repressed by the t inte...
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Article
“The End Game”- Students’ perspectives of the National Residency Matching Program: A focus group study
The evolving match process has resulted in increasing pressures on medical students, residency programs, and medical schools. These pressures have led to calls for reform of the National Residency Matching Pro...
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Article
Open AccessMolecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic
The PspC and Hic proteins of Streptococcus pneumoniae are some of the most variable microbial immune evasion proteins identified to date. Due to structural similarities and conserved binding profiles, it was assu...
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Article
Open AccessContribution of growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) to the regulation of social motivation in male mice
Most psychiatric disorders are characterized by deficits in the ability to interact socially with others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and appetite, is also...
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Article
Open AccessChanges in harm reduction service providers professional quality of life during dual public health emergencies in Canada
Harm reduction (HR) is a critical response to the pronounced toxicity deaths being experienced in Canada. HR providers report many benefits of their jobs, but also encounter chronic stress from structural ineq...