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Thermodynamic evidence for a field-angle-dependent Majorana gap in a Kitaev spin liquid
The exactly solvable Kitaev model of two-dimensional honeycomb magnets has a quantum spin liquid phase characterized by the emergence of fractionalized Majorana fermion excitations. In the paramagnetic state o...
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Article
A dusty compact object bridging galaxies and quasars at cosmic dawn
Understanding how super-massive black holes form and grow in the early Universe has become a major challenge1,2 since it was discovered that luminous quasars existed only 700 million years after the Big Bang3,4. ...
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Hopelessness and Depression Predict Sarcopenia in Advanced CKD and Dialysis: A Multicenter Cohort Study
Depression and hopelessness are frequently experienced in chronic kidney disease (CKD) and are generally associated with lessened physical activity. The aim of this study was to quantify the associations betwe...
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Open AccessReproductive interference in live-bearing fish: the male guppy is a potential biological agent for eradicating invasive mosquitofish
The eradication of invasive exotic species is desirable but often infeasible. Here, we show that male guppies are a potential biological agent for eradicating invasive mosquitofish through the mechanism of rep...
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Article
Multi-scale analysis on wake structures of asymmetric cylinders with different aspect ratios
The wake flow originated by three-dimensional bluff bodies having the different aspect ratio is experimentally studied in this paper. The turbulent wakes generated by asymmetric- and semi-cylinders were first ...
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Article
Colossal thermomagnetic response in the exotic superconductor URu2Si2
The Nernst coefficient is a measure of the transverse thermoelectric effect in a conductor. Superconducting fluctuations magnify this effect but in URu2Si2, the million-fold enhancement suggests that the fluctuat...
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Article
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice
Metformin, the major target of which is liver, is commonly used to treat type 2 diabetes. Although metformin activates AMP-activated protein kinase (AMPK) in hepatocytes, the mechanism of activation is still n...
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Article
Src activation generates reactive oxygen species and impairs metabolism–secretion coupling in diabetic Goto–Kakizaki and ouabain-treated rat pancreatic islets
Na+/K+-ATPase inhibition by ouabain suppresses ATP production by generating reactive oxygen species (ROS) and impairs glucose-induced insulin secretion from pancreatic islets. To clarify the signal-transducing fu...
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Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic islets
We have established a new method for allogeneic pancreatic islet (PI) transplantation: relatively low doses of irradiation followed by simultaneous transplantation of PIs and bone marrow cells (BMCs) via the p...
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Open AccessPromising survival for patients with glioblastoma multiforme treated with individualised chemotherapy based on in vitro drug sensitivity testing
We retrospectively investigated the efficacy and feasibility of individualised chemotherapy based on in vitro drug sensitivity testing (DST) for patients with glioblastoma multiforme. A total of 40 consecutive pa...
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Cytoreductive surgery combined with organ resection for advanced ovarian carcinoma
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Open AccessFrequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers
We found a significant correlation between lung cancer in smokers and the expression of a human gene, D40, predominantly expressed in testis and cancers. In an attempt to clone a novel human gene, we screened ...
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Article
Prognostic impact of platelet-derived growth factor in breast carcinoma patients with hematogenous metastasis
Background. Many recent studies have found that several angiogenic factors play an important role in primary and metastatic tumor growth. Platelet-derived growth factor (PDGF) is known to induce angiogenesis. In...
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Survival of patients on maintenance hemodialysis: emphasis on incidence of cerebro- and cardiovascular diseases
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Preload reduction by a single hemodialysis unmasks abnormal left ventricular inflow jet dynamics and early diastolic incoordinate long axis motion in patients on maintenance hemodialysis
Background. Our objective was to investigate changes in left ventricular inflow jet width and long axis motion in patients on maintenance hemodialysis by preload reduction due to a single hemodialysis.
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35th Annual Meeting of the European Association for the Study of Diabetes
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Universal conductance in quantum wires in the presence of Umklapp scattering
The effects of Umklapp scattering on the zero-temperature conductance in one-dimensional quantum wires are reexamined by taking into account both the screening of external potential and the non-uniform chemica...
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Article
Production of trehalose synthase from a basidiomycete, Grifola frondosa, in Escherichia coli
The genomic DNA and cDNA for a gene encoding a novel trehalose synthase (TSase) catalyzing trehalose synthesis from α-d-glucose 1-phosphate and d-glucose were cloned from a basidiomycete, Grifola frondosa. Nucle...
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Risk factors for neonatal thrombocytopenia in pregnancy complicated by idiopathic thrombocytopenic purpura
The aim of this study was to evaluate risk factors for the occurrence of fetal/neonatal passive immune thrombocytopenia (PIT) in pregnancy complicated with ITP. We studied 52 pregnancies with ITP and the 54 n...