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  1. Article

    Open Access

    A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia

    To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in pati...

    V Lévy, S Zohar, C Bardin, A Vekhoff, D Chaoui, B Rio… in British Journal of Cancer (2006)

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  2. Article

    Open Access

    Experimental designs for phase I and phase I/II dose-finding studies

    We review the rationale behind the statistical design of dose-finding studies as used in phase I and phase I/II clinical trials. We underline what the objectives of such dose-finding studies should be and why ...

    J O'Quigley, S Zohar in British Journal of Cancer (2006)

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