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Open AccessDandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying lymphocyte biology. Here we introduce Dandelion,...
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Article
Single-cell omics meets organoid cultures
Roser Vento-Tormo highlights the synergy of single-cell omics and organoids by Camp et al., who used single-cell RNA sequencing to characterize the cell–cell communication events driving tissue formation in hu...
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Open AccessAuthor Correction: Map** the temporal and spatial dynamics of the human endometrium in vivo and in vitro
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Article
Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in health and disease, but comprehensive map** of cell types in situ remains a challenge. Here we present сell2locat...
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Article
Open AccessMap** the temporal and spatial dynamics of the human endometrium in vivo and in vitro
The endometrium, the mucosal lining of the uterus, undergoes dynamic changes throughout the menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps of th...
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Article
A cellular census of human lungs identifies novel cell states in health and in asthma
Human lungs enable efficient gas exchange and form an interface with the environment, which depends on mucosal immunity for protection against infectious agents. Tightly controlled interactions between structu...
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Epigenetic control of myeloid cell differentiation, identity and function
The interplay between transcription factors and epigenetic regulators is crucial for regulating gene-expression programmes during haematopoiesis. Epigenetic re...