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Failure and exploitation of autophagy in human pathologies—cellular integrity between inflammation, infection, and cell survival
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Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
Mark Daly, Ramnik Xavier and colleagues report that a 20-kb deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn's disease. They also show that manipulation of IRGM levels i...
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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the pre...
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Open AccessThe human cadherin family protein hFat1 interacts with postsynaptic density PDZ domain-containing proteins