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A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes
Tiels et al. identify a bacterial glycosidase that facilitates improved modification of N-glycans on the Pompe disease enzyme α-glucosidase.
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Open AccessText-mining assisted regulatory annotation
Decoding transcriptional regulatory networks and the genomic cis-regulatory logic implemented in their control nodes is a fundamental challenge in genome biology. High-throughput computational and experimental an...