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Open AccessUltrafast relaxation of photoexcited superfluid He nanodroplets
The relaxation of photoexcited nanosystems is a fundamental process of light–matter interaction. Depending on the couplings of the internal degrees of freedom, relaxation can be ultrafast, converting electroni...
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Article
Complete reconstruction of bound and unbound electronic wavefunctions in two-photon double ionization
To be complete, the characterization of the photoionization process of atoms and molecules requires the extraction of all quantum-mechanical phases and amplitudes. So far, complete experiments have accessed on...
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Article
Open AccessSymmetry breakdown of electron emission in extreme ultraviolet photoionization of argon
Short wavelength free-electron lasers (FELs), providing pulses of ultrahigh photon intensity, have revolutionized spectroscopy on ionic targets. Their exceptional photon flux enables multiple photon absorption...
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Open AccessAcetylacetone photodynamics at a seeded free-electron laser
The first steps in photochemical processes, such as photosynthesis or animal vision, involve changes in electronic and geometric structure on extremely short time scales. Time-resolved photoelectron spectrosco...
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Coherent control with a short-wavelength free-electron laser
Researchers demonstrate correlation of two colours (63.0 and 31.5 nm wavelengths) in a free-electron laser and control photoelectron angular distribution by adjusting phase with 3 attosecond resolution.
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Determining the polarization state of an extreme ultraviolet free-electron laser beam using atomic circular dichroism
Ultrafast extreme ultraviolet and X-ray free-electron lasers are set to revolutionize many domains such as bio-photonics and materials science, in a manner similar to optical lasers over the past two decades. ...
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KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570
Mutation of KIT receptor tyrosine kinase at residue D816 results in ligand-independent constitutive kinase activity. This mutation occurs in most patients with mastocytosis, a myeloproliferative neoplasm, and ...
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Open AccessCollective Autoionization in Multiply-Excited Systems: A novel ionization process observed in Helium Nanodroplets
Free electron lasers (FELs) offer the unprecedented capability to study reaction dynamics and image the structure of complex systems. When multiple photons are absorbed in complex systems, a plasma-like state ...
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Article
Open AccessGenomic Grade Index predicts postoperative clinical outcome of GIST
Prognosis of localised gastrointestinal stromal tumour (GIST) is heterogeneous, notably for patients with AFIP intermediate or high risk of relapse, who are candidates to adjuvant imatinib. We hypothesised tha...
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Mutations and deletions of ARID1A in breast tumors
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Gene expression profiling identifies sST2 as an effector of ErbB2-driven breast carcinoma cell motility, associated with metastasis
Overexpression of the ErbB2 receptor tyrosine kinase in breast cancer contributes to tumor development and is associated with poor prognosis. However, the mechanism by which ErbB2 might contribute to metastasi...
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Open AccessA refined molecular taxonomy of breast cancer
The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression profiling have been proposed as alternatives. However, th...
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Open AccessA seven-gene prognostic model for platinum-treated ovarian carcinomas
Prognosis of ovarian carcinoma is poor, heterogeneous, and not accurately predicted by histoclinical features. We analysed gene expression profiles of ovarian carcinomas to identify a multigene expression mode...
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Gain of CBL-interacting protein, a possible alternative to CBL mutations in myeloid malignancies
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Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases
The t(8;16)(p11;p13) is a rare translocation involved in de novo and therapy-related myelomonocytic and monocytic acute leukemia. It fuses two genes encoding histone acetyltransferases (HATs), MYST3 located at 8p...
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Lobular and ductal carcinomas of the breast have distinct genomic and expression profiles
Invasive ductal carcinomas (IDCs) and invasive lobular carcinomas (ILCs) are the two major pathological types of breast cancer. Epidemiological and histoclinical data suggest biological differences, but little...
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ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines
Breast cancers that overexpress the ERBB2 tyrosine kinase receptor may be treated with the recombinant humanized monoclonal anti-ERBB2 antibody trastuzumab (herceptin). However, resistance to this targeted the...
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Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators
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Gene expression profiling of breast cell lines identifies potential new basal markers
A better molecular characterization of breast cell lines (BCL) may help discover new markers to apply to tumour samples. We performed gene and protein expression profiling of 31 BCL using whole-genome DNA micr...
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Molecular characterization of breast cell lines: a tool for breast cancer studies