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    Article

    Structural and functional characterization of the bestrophin-2 anion channel

    The bestrophin family of calcium (Ca2+)-activated chloride (Cl−) channels, which mediate the influx and efflux of monovalent anions in response to the levels of intracellular Ca2+, comprises four members in mamma...

    Aaron P. Owji, Qingqing Zhao, Changyi Ji… in Nature Structural & Molecular Biology (2020)

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    Article

    Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

    Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (β-arr). However, some GPCRs continue to signal throu...

    Anthony H. Nguyen, Alex R. B. Thomsen… in Nature Structural & Molecular Biology (2019)