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  1. No Access

    Article

    Cytotoxic activity of new racemic and optically active N-phosphonoalkyl bicyclic β-amino acids against human malignant cell lines

    The cytotoxic effects of novel racemic and optically active constrained N-phosphonoalkyl bicyclic β-amino acids were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited d...

    Petar T. Todorov, Diana W. Wesselinova, Nikola D. Pavlov, Jean Martinez… in Amino Acids (2012)

  2. No Access

    Article

    Synthesis and biological activity of new series of N-modified analogues of the N/OFQ(1–13)NH2 with aminophosphonate moiety

    New series of N-modified analogues of the N/OFQ(1–13)NH2 with aminophosphonate moiety have been synthesized and investigated for biological activity. These peptides were prepared by solid-phase peptide synthesis—...

    Petar T. Todorov, Polina I. Mateeva, Rositza N. Zamfirova, Nikola D. Pavlov… in Amino Acids (2012)

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    Article

    Synthesis and biological activity of novel small peptides with aminophosphonates moiety as NOP receptor ligands

    The aim of the present study was the synthesis and the biological screening of new analogs of Ac-RYYRWK-NH2, modified at the N-terminal with 1-[(methoxyphosphono)methylamino]cycloalkanecarboxylic acids. The four ...

    Emilia D. Naydenova, Petar T. Todorov, Polina I. Mateeva… in Amino Acids (2010)