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Article
Interobserver variability amongst gastrointestinal pathologists in assessing prognostic parameters of malignant colorectal polyps: a cause for concern
Malignant colorectal polyps (MCRP) have become a major challenge in the field of coloproctology from diagnosis to full treatment. One important facet of the challenge is the histopathological staging of the le...
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Article
Inflammatory bowel disease: the problems of dysplasia and surveillance
Patients with ulcerative colitis and colonic Crohn’s disease are at an increased risk of develo** colorectal malignancy. The reporting of such cases in the literature has led to the identification of a numbe...
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Article
Indeterminate colitis
The term indeterminate colitis has been used to describe cases of inflammatory bowel disease that cannot be classified as ulcerative colitis or Crohn’s disease. However, this term has suffered varying definiti...
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Article
Colonic neoplastic polyps: biopsy is not efficient to exclude malignancy. The Trafford experience
The biological behaviour of the polyp depends entirely on its histological subtype. Adenomas are the classic precursors to carcinoma. Polyp biopsy can differentiate neoplastic (adenoma and carcinoma) from non-...
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Article
Appendicular intussusception into a polyp
Intussusception of the appendix is a rare condition. We present the case of a 72–year–old woman with multiple polyps in the colon with an appendix completely intussuscepted into a polyp within the caecum. The ...
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Article
Improved diagnostic accuracy of inflammatory bowel disease: a clinicopathological collaborative approach
Although colonic biopsies have become a major source of information to the clinician investigating cases of inflammatory bowel diseases (IBD), there are still some difficulties in making definitive diagnoses. ...
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Article
Snaring of submucosal tumors of gastric fundus
Submucosal tumors of the stomach are not uncommon. We present two cases of iatrogenic perforation after snaring large polyps in the gastric fundus. We discuss the probable etiology and review the literature re...
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Article
Open AccessAre differences in stage at presentation a credible explanation for reported differences in the survival of patients with colorectal cancer in Europe?
Popular reporting of a comparison of cancer survival rates across 17 European countries, based on data collected by national and regional cancer registries, has left an impression of inadequate treatment of pa...
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Article
Diagnosis and treatment of diverticular disease
Background: With the aim of resolving the current controversy over the diagnosis and treatment of diverticular disease, this consensus development conference set out to summarize the actual state...
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Article
The novel combination of fat clearance and immunohistochemistry improves prediction of the outcome of patients with colorectal carcinomas: a preliminary study
To evaluate the significance of micrometastases in relation to survival rate, specimens from 48 colorectal carcinoma patients were analysed after fat clearance. The number and size of the lymph nodes harbouri...
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Article
Gelatinase B (MMP-9) expression and survival in colorectal cancer patients
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Article
Histopathological changes in haemorrhoid associated mucosa and submucosa
The histological features of haemorrhoids are detailed in this study with special attention to the mucosal changes. These include significant crypt distortion, wiht stromal hyperplasia which bear a remarkable ...
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Article
Distribution of gelatinase B (MMP-9) and type IV collagen in colorectal carcinoma
Gelatinase B (92 kD matrix metalloproteinase-9, MMP-9), an enzyme capable of degrading several connective tissue components, was demonstrated by immunolocalization in all specimens of colorectal carcinoma (n=40),...