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Open AccessAn efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons
We have developed a highly effective method for in vivo gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of synthetic, small interfering RNA (siRNA). A siRN...
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Dynorphin A activates bradykinin receptors to maintain neuropathic pain
Dynorphin A is an endogenous opioid peptide that produces non-opioid receptor-mediated neural excitation. Here we demonstrate that dynorphin induces calcium influx via voltage-sensitive calcium channels in sen...