21 Result(s)

Article

Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan

This update summarizes key changes made to the protocol for the Frequency of Screening and Spontaneous Breathing Trial (SBT) Technique Trial—North American Weaning Collaborative (FAST-NAWC) trial since the pub...

Karen E. A. Burns, Myriam Lafrienier-Roula, Nicholas S. Hill, Deborah J. Cook… in Trials (2023)

Article

Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study)

The quality of clinical care of brain-dead potential organ donors may help reduce donor losses caused by irreversible or unreversed cardiac arrest and increase the number of organs donated. We sought to determ...

Natalia Elis Giordani, Caroline Cabral Robinson, Glauco Adrieno Westphal… in Trials (2020)

Article

Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study

Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying ...

Daphnée Lamarche, Jennie Johnstone, Nicole Zytaruk, France Clarke… in RESPIRATORY RESEARCH (2018)

Article

Furosemide and albumin for diuresis of edema (FADE): a study protocol for a randomized controlled trial

Fluid retention is a common complication of critical illness. It typically results from large-volume fluid infusions during acute resuscitation and is worsened by hypoalbuminemia. Recognized as edema, fluid re...

Simon JW Oczkowski, Ian Mazzetti, Maureen O Meade, Cindy Hamielec in Trials (2014)

Article

Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials

Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncer...

Waleed Alhazzani, Mohamed Alshahrani, Roman Jaeschke, Jean Marie Forel… in Critical Care (2013)

Article

Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation?

Prone ventilation (PV) is a ventilatory strategy that frequently improves oxygenation and lung mechanics in critical illness, yet does not consistently improve survival. While the exact physiologic mechanisms ...

Andrew W Kirkpatrick, Paolo Pelosi, Jan J De Waele, Manu LNG Malbrain… in Critical Care (2010)

Article

Wean Earlier and Automatically with New technology (the WEAN study): a protocol of a multicentre, pilot randomized controlled trial

Weaning is the process during which mechanical ventilation is withdrawn and the work of breathing is transferred from the ventilator back to the patient. Prolonged weaning is associated with development of ven...

Karen EA Burns, Maureen O Meade, Martin R Lessard, Sean P Keenan… in Trials (2009)

Article

Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death

Jan O Friedrich, Neill KJ Adhikari, Maureen O Meade in Critical Care (2006)

Article

Drotrecogin alfa (activated): down and not out, but not really in either

Jan O Friedrich, Neill KJ Adhikari, Maureen O Meade in Critical Care (2006)

Article

Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?

Two international multicentre randomised controlled trials of drotrecogin alfa (activated) (DrotAA), the Recombinant Human Activated Protein C Worldwide Evaluation of Severe Sepsis (PROWESS) and Administration...

Jan O Friedrich, Neill KJ Adhikari, Maureen O Meade in Critical Care (2006)

Article

Neuroanesthesia and Intensive Care A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation

To summarize the evidence comparing noninvasive positive pressure ventilation (NPPV) and invasive positive pressure ventilation (IPPV) weaning on mortality, ventilator associated pneumonia and the total durati...

Karen E.A.Burns, Neill K.J Adhikari, Maureen O Meade in Canadian Journal of Anesthesia (2006)

Article

Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility

A few recent, large, well-publicized trials in critical care medicine have been stopped for futility. In the critical care setting, stop** for futility means that independent review committees have elected t...

David A Schoenfeld, Maureen O Meade in Critical Care (2004)

Article

In collaboration with the Canadian Critical Care Society, the Canadian Journal of Anesthesia is proud to publish the best posters presented at the Toronto Critical Care Medicine Symposium 2003 (Adult and Pediatric) held in Toronto, Ontario, October 30 – November 1, 2003

Conan McCaul, Patrick McNamara, Doreen Engelberts… in Canadian Journal of Anesthesia (2004)

Article

The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients

To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically ventilated critically ill patients.

Deborah J Cook, Lauren E Griffith, Stephen D Walter, Gordon H Guyatt… in Critical Care (2001)

Article

Outcome Measures: Methodologic Principles

Gordon H. Guyatt, Maureen O. Meade in Sepsis (1997)