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Masahiro Noji
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Article
Open AccessBreakdown of supersaturation barrier links protein folding to amyloid formation
The thermodynamic hypothesis of protein folding, known as the “Anfinsen’s dogma” states that the native structure of a protein represents a free energy minimum determined by the amino acid sequence. However, i...
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Article
Open AccessMacromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis
Dialysis-related amyloidosis (DRA), a serious complication among long-term hemodialysis patients, is caused by amyloid fibrils of β2-microglobulin (β2m). Although high serum β2m levels and a long dialysis vint...
