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Article
Systemic high-dose intravenous methotrexate for central nervous system metastases
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Article
Systemic high-dose intravenous methotrexate for central nervous system metastases
Treatment options for patients with recurrent central nervous system (CNS) metastases are limited. Rapid infusion of high-dose intravenous methotrexate (HD IV MTX) penetrates the blood-brain barrier (BBB) and ...
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Article
Necrotizing vasculopathy of the CNS: case report
A 62-year-old man with progressive cerebellar and brainstem dysfunction had gadolinium-enhancing lesions in basal ganglia and occipital lobe on MRI suggestive of primary CNS lymphoma (PCNSL). The patient, who ...
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Article
Leptomeningeal metastases from recurrent squamous cell cancer of the skin
We report two patients with leptomeningeal metastases from squamous cell cancer of the skin. In one patient cauda equina metastases appeared 6 years after initial presentation; the tumor from radical neck diss...
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Article
Primary Leptomeningeal Primitive Neuroectodermal Tumor
Leptomeningeal metastases are a common complication of medulloblastomas and other primitive neuroectodermal tumors (PNETs). Much rarer are PNETs apparently arising in the leptomeninges. An 8-year-old boy prese...
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Article
Genomic changes in glioblastoma cell lines detected by comparative genomic hybridization
Comparative genomic hybridization serves as a screening test for regions of copy number changes in tumor genomes. We have applied the technique to map DNA gains and losses in 5 cell lines derived from glioblas...