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  1. Article

    Open Access

    Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy

    Reversion mutations that restore wild-type function of the BRCA gene have been described as a key mechanism of resistance to Poly(ADP-ribose) polymerase (PARP) inhibitor therapy in BRCA-associated cancers. Here, ...

    Charlotte S. Walmsley, Philip Jonsson, Michael L. Cheng… in npj Precision Oncology (2024)

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  2. No Access

    Article

    Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer

    The incidence of rectal cancer is increasing in patients younger than 50 years. Locally advanced rectal cancer is still treated with neoadjuvant radiation, chemotherapy and surgery, but recent evidence suggest...

    Walid K. Chatila, ** K. Kim, Henry Walch, Michael R. Marco… in Nature Medicine (2022)

  3. No Access

    Article

    Genome doubling shapes the evolution and prognosis of advanced cancers

    Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors of nearly 30% of 9,692 prospec...

    Craig M. Bielski, Ahmet Zehir, Alexander V. Penson, Mark T. A. Donoghue… in Nature Genetics (2018)

  4. No Access

    Article

    ALCAM is indirectly modulated by miR-125b in MCF7 cells

    MicroRNA (miRNA) deregulation is associated with various cancers. Among an expanding list of cancer-related miRNAs, deregulation of miR-125b has been well documented in many cancers including breast. Based on ...

    H. Begum Akman, S. Duygu Selcuklu, Mark T. A. Donoghue… in Tumor Biology (2015)