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  1. Article

    Open Access

    Cell type discovery and representation in the era of high-content single cell phenoty**

    A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal func...

    Trygve Bakken, Lindsay Cowell, Brian D. Aevermann, Mark Novotny… in BMC Bioinformatics (2017)

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  2. No Access

    Article

    Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

    This protocol describes how to sequence the transcriptome from a single nucleus. It is particularly suited to cell types that are difficult to isolate as intact whole cells, such as neurons.

    Suguna Rani Krishnaswami, Rashel V Grindberg, Mark Novotny… in Nature Protocols (2016)

  3. No Access

    Article

    Efficient de novo assembly of single-cell bacterial genomes from short-read data sets

    DNA can be amplified and sequenced from a single cell, but unevenness of the sequence coverage complicates efforts to assemble a high-quality genome. Chitsaz et al. devise an algorithm to address this problem and...

    Hamidreza Chitsaz, Joyclyn L Yee-Greenbaum, Glenn Tesler… in Nature Biotechnology (2011)

  4. No Access

    Article

    A modified walking rhythm employed during righting behavior in the cockroachGromphadorhina portentosa

    Electromyograms were recorded from leg muscles of the cockroachGromphadorhina during walking and righting under free-ranging and tethered conditions. Two muscles which are essentially synergistic during walking b...

    Elizabeth Sherman, Mark Novotny, Jeffrey M. Camhi in Journal of comparative physiology (1977)