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  1. Article

    Open Access

    Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling

    Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not p...

    Sara Vanessa Bernhard, Katarzyna Seget-Trzensiok, Christian Kuffer… in Cellular Oncology (2022)

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  2. Article

    Open Access

    The p53/p73 - p21CIP1 tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells

    Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitos...

    Ann-Kathrin Schmidt, Karoline Pudelko, Jan-Eric Boekenkamp, Katharina Berger… in Oncogene (2021)

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    Article

    Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer

    Regulators of transition through mitosis such as SURVIVIN and Aurora kinase A (AURKA) have been previously implicated in the initiation of chromosomal instability (CIN), a driver of intratumour heterogeneity. ...

    Rebecca Roylance, David Endesfelder… in Breast Cancer Research and Treatment (2014)