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Article
hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness
Stress hormones have been implicated in both tumor initiation and progression. Human telomerase reverse transcriptase (hTERT) is overexpressed in cancer cells and associated with malignant tumor progression an...
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Article
Open AccessRAF kinase inhibitor-independent constitutive activation of Yes-associated protein 1 promotes tumor progression in thyroid cancer
The transcription coactivator Yes-associated protein 1 (YAP1) is regulated by the Hippo tumor suppressor pathway. However, the role of YAP1 in thyroid cancer, which is frequently associated with the BRAFV600E mut...
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Article
Association between a G-protein β3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders
The genes involved in signal transduction are major candidates in association studies on affective disorders and responses to antidepressants. We investigated whether the C825T polymorphism of the β3 subunit o...