16 Result(s)

Article

The contribution of genetics and epigenetics to MAFLD susceptibility

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of develo** MAFLD varies among individuals, due to a combination of environmental inherited a...

Vittoria Moretti, Stefano Romeo, Luca Valenti in Hepatology International (2024)

Article

Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner… in Nature Reviews Endocrinology (2024)

Article

Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study

No univocal recommendation exists for microbiological diagnosis of ventilator-associated pneumonia (VAP). Sampling of either proximal or distal respiratory tract likely impacts on the broad range of VAP incide...

Davide Mangioni, Mauro Panigada, Emanuele Palomba, Chiara Bobbio… in Critical Care (2023)

Article

Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron ...

Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner… in Nature Reviews Endocrinology (2023)

Article

Correction to: Usefulness of Fibrosis-4 (FIB-4) score and metabolic alterations in the prediction of SARS-CoV-2 severity

Rosa Lombardi, Vincenzo La Mura, Annalisa Cespiati… in Internal and Emergency Medicine (2022)

Article

Usefulness of fibrosis-4 (FIB-4) score and metabolic alterations in the prediction of SARS-CoV-2 severity

Despite vaccination programs, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains a public health problem. Identifying key prognostic determinants of severity of the disease may help...

Rosa Lombardi, Vincenzo La Mura, Annalisa Cespiati… in Internal and Emergency Medicine (2022)

Article

Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank

Obesity is among the main determinants of nonalcoholic fatty liver disease progression towards severe liver disease (SLD). However, risk factors for SLD in individuals with obesity have not been examined.

Antonio De Vincentis, Federica Tavaglione… in International Journal of Obesity (2022)

Article

Advancing the global public health agenda for NAFLD: a consensus statement

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-rang...

Jeffrey V. Lazarus, Henry E. Mark… in Nature Reviews Gastroenterology & Hepatolo… (2022)

Article

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis

Aim of this study was to evaluate whether the A736V TMPRSS6 polymorphism, a major genetic determinant of iron metabolism in healthy subjects, influences serum levels of hepcidin, the hormone regulating iron me...

Serena Pelusi, Domenico Girelli, Raffaela Rametta, Natascia Campostrini… in BMC Nephrology (2013)

Article

The i148m Pnpla3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls

Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism pre...

Luca Valenti, Raffaela Rametta, Massimiliano Ruscica… in BMC Gastroenterology (2012)

Article

IL28B, HCV core mutations, and hepatocellular carcinoma: does host genetic make-up shape viral evolution in response to immunity?

Mutations in the core sequence of the HCV genome have been reported to influence treatment response, fibrosis progression, and hepatocarcinogenesis in Asian patients with genotype-1 chronic hepatitis C (CHC). ...

Luca Valenti, Edoardo Pulixi, Susanna La Spina in Hepatology International (2012)

Article

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

Peroxisome proliferator-activated receptors (PPARs) play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).

Paola Dongiovanni, Raffaela Rametta, Anna Ludovica Fracanzani… in BMC Gastroenterology (2010)