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Article
Open AccessFractal dimensions and machine learning for detection of Parkinson’s disease in resting-state electroencephalography
Parkinson’s disease (PD) is an incurable neurological disorder that degenerates the cerebrospinal nervous system and hinders motor functions. Electroencephalography (EEG) signal analysis can provide reliable i...
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Article
Open AccessAutophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors
A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeut...
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Article
Open AccessAn 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma
The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.
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Article
Open AccessPerhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA
High Risk Neuroblastoma (HR-NB) is a pediatric cancer characterized by high malignancy and remarkable cell heterogeneity within the tumour nodules. In a recent study, we demonstrated that in vitro and in vivo ove...
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Article
Open AccessInhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines
The Anaplastic Lymphoma Kinase (ALK) is an orphan receptor tyrosine kinase, which undergoes post-translational N-linked glycosylation. The catalytic domain of ALK was originally identified in the t(2;5) transl...
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Article
Identification of ALK as a major familial neuroblastoma predisposition gene
Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely unknown. Here we show that germline mutations in the anaplastic lymphoma kinase (ALK) gene explain most hereditary n...
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Article
PHOX2B mutations and genetic predisposition to neuroblastoma
Neuroblastoma (NB) is a childhood malignancy originating from neural crest cells, which seldom occurs in association with other neurocristopathies. Owing to the rarity of familial NB cases, only a few linkage ...
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Article
Weak linkage at 4p16 to predisposition for human neuroblastoma
The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal inter...
