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  1. No Access

    Article

    The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study

    The role of CD3+CD56+ natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially r...

    Sheng-long Chen, **ao-yu Liu, Jun-hong Huang, Lu-hua **an… in Immunologic Research (2023)

  2. Article

    Open Access

    Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis

    Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear. This study aims to investig...

    Song Hu, Zhennan Lin, Meng-** Hu, Jiang-Shan Tan… in Journal of Translational Medicine (2023)

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  3. No Access

    Article

    Plasma metabolomics in the perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease

    The quality of life and survival rates of patients with pulmonary arterial hypertension associated with congenital heart disease (CHD–PAH) have been greatly improved by defect-repair surgery and personalized t...

    Yang-yang He, Yi Yan, Ji-wang Chen, Sheng Liu, Lu Hua… in Acta Pharmacologica Sinica (2022)

  4. Article

    Open Access

    Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation

    The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcir...

    Fan He, Lu Hua, Tingting Guo in Theoretical Biology and Medical Modelling (2021)

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  5. No Access

    Article

    Lipocalin-2 Predicts Long-Term Outcome of Normotensive Patients with Acute Pulmonary Embolism

    Normotensive patients with acute pulmonary embolism (APE) are accompanied by heterogeneously adverse events. Responding to tissue injury, lipocalin-2 (LCN-2) is elevated in experimental APE model and associate...

    Haixu Yu, Zhuohui Liu, Jie Lu, **nying Yang, **n-**n Yan… in Cardiovascular Toxicology (2020)

  6. No Access

    Article

    Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

    Chinese herbal medicine (CHM) addresses complex diseases through polypharmacological interactions. However, systematic studies of herbal medicine pharmacology remain challenging due to the complexity of CHM in...

    Shuo Gu, Lu-hua Lai in Acta Pharmacologica Sinica (2020)

  7. No Access

    Article

    Knockdown of DIXDC1 Inhibits the Proliferation and Migration of Human Glioma Cells

    DIX domain containing 1 (DIXDC1), the human homolog of coiled-coil-DIX1 (Ccd1), is a positive regulator of Wnt signaling pathway. Recently, it was found to act as a candidate oncogene in colon cancer, non-smal...

    Jianguo Chen, Chaoyan Shen, **long Shi… in Cellular and Molecular Neurobiology (2017)