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Article
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos
During the first lineage segregation, a mammalian totipotent embryo differentiates into the inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) regulate this earliest cell-fa...
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Article
Open AccessNR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast arises, and extraembryonic trophec...
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Article
Open AccessDNA methylation and lipid metabolism are involved in GA-induced maize aleurone layers PCD as revealed by transcriptome analysis
The aleurone layer is a part of many plant seeds, and during seed germination, aleurone cells undergo PCD, which is promoted by GA from the embryo. However, the numerous components of the GA signaling pathway ...
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Article
Which One Is the “Best”: a Cross-national Comparative Study of Students’ Strategy Evaluation in Equation Solving
This cross-national study examined students’ evaluation of strategies for solving linear equations, as well as the extent to which their evaluation criteria were related to their use of strategies and/or align...
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Article
SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling
Mitotic catastrophe (MC) is a suppressive mechanism that mediates the elimination of mitosis-deficient cells through apoptosis, necrosis or senescence after M phase block. SIRT1 is involved in the regulation o...
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Article
Open AccessExploring students’ procedural flexibility in three countries
In this cross-national study, Spanish, Finnish, and Swedish middle and high school students’ procedural flexibility was examined, with the specific intent of determining whether and how students’ equation-solv...
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Article
Open AccessHedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells
Although HHIP locus has been consistently associated with the susceptibility to COPD including airway remodeling and emphysema in genome-wide association studies, the molecular mechanism underlying this geneti...
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Article
Characteristic and evolution of HAT and HDAC genes in Gramineae genomes and their expression analysis under diverse stress in Oryza sativa
Comprehensive characterization of Gramineae HATs and HDACs reveals their conservation and variation. The recent WGD/SD gene pairs in the CBP and RPD/HDA1 gene family may confer specific adaptive evolutionary chan...
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Article
Open AccessNutritional quality improvement of soybean meal by Bacillus velezensis and Lactobacillus plantarum during two-stage solid- state fermentation
Bacillus velezensis is widely used for agricultural biocontrol, due to its ability to enhance plant growth while suppressing the growth of microbial pathogens. However, there are few reports on its application in...
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Article
The landscape of RNA Pol II binding reveals a stepwise transition during ZGA
Zygotic genome activation (ZGA) is the first transcription event in life1. However, it is unclear how RNA polymerase is engaged in initiating ZGA in mammals. Here, by develo** small-scale Tn5-assisted chromatin...
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Article
Open AccessIdentification and characterization of abundant repetitive sequences in Allium cepa
Species of the genus Allium are well known for their large genomes. Allium cepa is of great economic significance. Among vegetables, it ranks second after tomato in terms of the global production value. However, ...
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Article
Dynamic changes in histone modification are associated with upregulation of Hsf and rRNA genes during heat stress in maize seedlings
Histone modification plays a significant role in plant responses to abiotic stress. However, there are little scientific studies available on the involvement of dynamic changes in histone modification in the h...
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Article
Application of the Reactive Oxygen-Based Cervical Exfoliated Cell Staining Solution in Clinical Cervical Cancer Screening
We developed a special methylene blue solution for staining of cervix shedding cells based on catalytic oxidizing chromogenic reaction, which shows a potential for cervical cancer cytology screening. We screen...
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Article
Publisher Correction: p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
In Fig. 1c of this Letter, the labels p53+/+ and p53−/− were inadvertently swapped. The original figure has been corrected online.
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Article
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis
Cancer cells exhibit altered and usually increased metabolic processes to meet their high biogenetic demands1,2. Under these conditions, ammonia is concomitantly produced by the increased metabolic processing. Ho...
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Article
Open AccessTAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
The Warburg effect is a prominent metabolic feature associated with neoplastic diseases; however, the underlying mechanism remains incompletely understood. TAp73, a structural homolog of the tumor suppressor p...
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Article
Open AccessStructure of the human activated spliceosome in three conformational states
During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (Bact complex), which has a well-formed active site but cannot proceed to the branchin...
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Article
Histone acetylation is involved in GA-mediated 45S rDNA decondensation in maize aleurone layers
The aleurone layer is crucial to seed germination. Using dissected aleurone layers, we found that GA increased histone acetylation accompanied by rDNA decondensation in aleurone layers during m...
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Article
Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots
Histone acetylation plays a critical role in controlling chromatin structure, and reactive oxygen species (ROS) are involved in cell cycle progression. To study the relationship between histone acetylation and...
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Article
Open AccessMolecular dynamics investigations of mechanical behaviours in monocrystalline silicon due to nanoindentation at cryogenic temperatures and room temperature
Molecular dynamics simulations of nanoindentation tests on monocrystalline silicon (010) surface were conducted to investigate the mechanical properties and deformation mechanism from cryogenic temperature bei...
