44 Result(s)
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Article
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Blood vessels and nerves are complex, branched structures that share a high degree of anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure proper wiring of both syste...
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Article
Open AccessMolecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China
Human rhinovirus-C (HRV-C) has been increasingly detected in patients with acute respiratory diseases (ARDs). Prolonged surveillance was performed on children with ARD to investigate the molecular epidemiology...
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Article
Giant enhancement in vertical conductivity of stacked CVD graphene sheets by self-assembled molecular layers
Layer-by-layer-stacked chemical vapour deposition (CVD) graphene films find applications as transparent and conductive electrodes in solar cells, organic light-emitting diodes and touch panels. Common to lamel...
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Open AccessImpacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children
Increasing evidence suggests that altered intestinal microbial composition and function result in an increased risk of Clostridium difficile-associated diarrhoea (CDAD); however, the specific changes of intestina...
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Controlling the direction of rectification in a molecular diode
A challenge in molecular electronics is to control the strength of the molecule–electrode coupling to optimize device performance. Here we show that non-covalent contacts between the active molecular component...
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Article
Open AccessMechanistic Insights into Elastin Degradation by Pseudolysin, the Major Virulence Factor of the Opportunistic Pathogen Pseudomonas aeruginosa
Pseudolysin is the most abundant protease secreted by Pseudomonas aeruginosa and is the major extracellular virulence factor of this opportunistic human pathogen. Pseudolysin destroys human tissues by solubilizin...
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Open AccessNodulation Characterization and Proteomic Profiling of Bradyrhizobium liaoningense CCBAU05525 in Response to Water-Soluble Humic Materials
The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on th...
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Open AccessIdentification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing
Familial hypercholesterolaemia (FH) is a serious genetic metabolic disease. We identified a specific family in which the proband had typical homozygous phenotype of FH, but couldn’t detect any mutations in usu...
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Erratum: Identification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing
Familial hypercholesterolaemia (FH) is a serious genetic metabolic disease. We identified a specific family in which the proband had typical homozygous phenotype of FH, but couldn’t detect any mutations in usu...
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Article
Open AccessCavity enhanced atomic magnetometry
Atom sensing based on Faraday rotation is an indispensable method for precision measurements, universally suitable for both hot and cold atomic systems. Here we demonstrate an all-optical magnetometer where th...
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Open AccessApoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ population of tumor-infil...
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Open AccessThe distribution and characteristics of LDL receptor mutations in China: A systematic review
Familial hypercholesterolemia (FH) is a common and serious dominant genetic disease and its main pathogenic gene is the low-density lipoprotein receptor (LDLR) gene. This study aimed to perform a systematic re...
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Open AccessA triterpenoid from wild bitter gourd inhibits breast cancer cells
The antitumor activity of 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (TCD), a triterpenoid isolated from wild bitter gourd, in breast cancer cells was investigated. TCD suppressed the proliferation of MCF-7 ...
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Open AccessA Single-Level Tunnel Model to Account for Electrical Transport through Single Molecule- and Self-Assembled Monolayer-based Junctions
We present a theoretical analysis aimed at understanding electrical conduction in molecular tunnel junctions. We focus on discussing the validity of coherent versus incoherent theoretical formulations for sing...
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Article
Open AccessPurifying selection shapes the coincident SNP distribution of primate coding sequences
Genome-wide analysis has observed an excess of coincident single nucleotide polymorphisms (coSNPs) at human-chimpanzee orthologous positions and suggested that this is due to cryptic variation in the mutation ...
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Open AccessPharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy
Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However, some of these PTZs have been reported to exhibit antitumor effects by targeting various signaling pathways in vitro and in ...
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Article
Open AccessChemical control over the energy-level alignment in a two-terminal junction
The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular t...
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Open AccessThe use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia
Familial hypercholesterolemia (FH) is an autosomal dominant disorder. Although genetic testing is an important tool for detecting FH-causing mutations in patients, diagnostic methods for young patients with se...
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Article
Open AccessEndotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis
Peripheral CD27+ memory B-cells become quantitatively reduced and dysfunctional in patients with cirrhosis through poorly characterized mechanisms. We hypothesized that the disappearance of CD27+ memory B-cells r...
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Open AccessThe influence of postharvest UV-C treatment on anthocyanin biosynthesis in fresh-cut red cabbage
Red cabbage (Brassica oleracea L. var. capitata f. rubra DC.) is a fresh edible vegetable consumed globally that contains high levels of antioxidant compounds including anthocyanins. In this study, fresh-cut red ...
