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Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Open AccessDe novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation
The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovar...
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Article
Open AccessDysregulated dendritic cells in sepsis: functional impairment and regulated cell death
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Studies have indicated that immune dysfunction plays a central role in the pathogenesis of sepsis. D...
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Article
Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Open AccessCorrection: Cold exposure protects against medial arterial calcification development via autophagy
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Open AccessAdvances in nanomedicines for lymphatic imaging and therapy
Lymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, the unique physiological structure of lymph nodes has traditionally constrained the drug delivery effici...
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Article
Open AccessCold exposure protects against medial arterial calcification development via autophagy
Medial arterial calcification (MAC), a systemic vascular disease different from atherosclerosis, is associated with an increased incidence of cardiovascular events. Several studies have demonstrated that ambie...
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Article
Open AccessQuantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution
Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report bisulfite-induced deletion sequencing...
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Article
Open AccessMetabolic engineering of Escherichia coli for direct production of vitamin C from D-glucose
Production of vitamin C has been traditionally based on the Reichstein process and the two-step process. However, the two processes share a common disadvantage: vitamin C cannot be directly synthesized from D-...
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Open AccessA clinical trial of super-stable homogeneous lipiodol-nanoICG formulation-guided precise fluorescent laparoscopic hepatocellular carcinoma resection
Applying traditional fluorescence navigation technologies in hepatocellular carcinoma is severely restricted by high false-positive rates, variable tumor differentiation, and unstable fluorescence performance.
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Open AccessNovel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo
The interactions between nanoparticles (NPs) and plasma proteins form a protein corona around NPs after entering the biological environment, which provides new biological properties to NPs and mediates their i...
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Article
Open AccessHepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7
A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However...
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Open AccessSynthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine
Myricetin derivatives containing sulfonylpiperazine were synthesized and their structures were confirmed by NMR and HRMS. The antibacterial activity results indicated that some compounds showed good antibacter...
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Article
Open AccessBiochar-mediated enhanced ethanol fermentation (BMEEF) in Zymomonas mobilis under furfural and acetic acid stress
Pretreatment of lignocellulosic biomass generates different types of inhibitors (e.g., furfural and acetic acid), which could remarkably inhibit subsequent ethanol fermentation. Here, biochar as an additive in...
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Article
Size-Dependent Association of Cobalt Deuteride Cluster Anions Co3Dn− (n = 0–4) with Dinitrogen
Dinitrogen (N2) activation by metal hydride species is of fundamental interest and practical importance while the role of hydrogen in N2 activation is not well studied. Herein, the structures of Co3Dn− (n = 0–4) ...
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Article
Open AccessA novel microemulsion-based isotonic perfusate modulated by Ringer’s solution for improved microdialysis recovery of liposoluble substances
Microdialysis is promising technique for dynamic microbiochemical sampling from tissues. However, the application of typical aqueous perfusates to liposoluble substances is limited. In this study, a novel micr...
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Open AccessPurification and characterization of neutral protease from Aspergillus oryzae Y1 isolated from naturally fermented broad beans
The strain Y1, with a notably high production of neutral protease, was isolated from naturally fermented broad beans and subsequently identified as Aspergillus oryzae, through the analysis of its morphology chara...
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Article
Design and Application of a High-Temperature Linear Ion Trap Reactor
A high-temperature linear ion trap reactor with hexapole design was homemade to study ion–molecule reactions at variable temperatures. The highest temperature for the trapped ions is up to 773 K, which is much...
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Article
Open AccessReplacing process water and nitrogen sources with biogas slurry during cellulosic ethanol production
Environmental issues, such as the fossil energy crisis, have resulted in increased public attention to use bioethanol as an alternative renewable energy. For ethanol production, water and nutrient consumption ...
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Article
Open AccessOptimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01
Streptomyces kanasenisi ZX01 was found to produce a novel glycoprotein GP-1 previously, which was secreted into medium and had significant activity against tobacco mosaic virus. However, ...