318 Result(s)

Article

ALKBH4 impedes 5-FU Sensitivity through suppressing GSDME induced pyroptosis in gastric cancer

5-Fluorouracil (5-FU) is the primary treatment option for advanced gastric cancer. However, the current challenge lies in the absence of validated biomarkers to accurately predict the efficacy and sensitivity ...

**n Jiang, Zhiman Zhu, Lina Ding, Wenqi Du, Dongsheng Pei in Cell Death & Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

Author Correction: A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2024)

Article

Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma

Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) in the pathogene...

Wahafu Alafate, Gen Lv, Jiantao Zheng, Hai** Cai, Wei Wu… in Cell Death & Disease (2024)

Article

U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis

U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome pass...

Yang Jiang, Shiqi Sun, **aofeng Liu, Kunqi Su, Chunfeng Zhang… in Cell Death & Disease (2024)

Article

E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA

Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...

Yunyan Du, Zhangjian Yang, Hao Shi, Zhihan Chen, Rong Chen… in Cell Death & Disease (2024)

Article

GATA4 regulates the transcription of MMP9 to suppress the invasion and migration of breast cancer cells via HDAC1-mediated p65 deacetylation

GATA-binding protein 4 (GATA4) is recognized for its significant roles in embryogenesis and various cancers. Through bioinformatics and clinical data, it appears that GATA4 plays a role in breast cancer develo...

Yuxi Yang, Shuangshuang Song, Shu**g Li, Jie Kang, Yulin Li… in Cell Death & Disease (2024)

Article

Inter- and trans-generational impacts of real-world PM_2.5 exposure on male-specific primary hypogonadism

Exposure to PM_2.5, a harmful type of air pollution, has been associated with compromised male reproductive health; however, it remains unclear whether such exposure can elicit transgenerational effects on male fe...

**aoyu Wei, Zhonghao Zhang, Yayun Gu, Rong Zhang, Jie Huang, Feng Li… in Cell Discovery (2024)

Article

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang… in Cell Death & Disease (2024)

Article

TRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis

Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted b...

Zehua Zhang, **aohan Yan, Le Kang, Zhuyun Leng, Yingjie Ji… in Cell Death & Disease (2024)

Article

Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21

Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In this study, we investigated the impact of NAFLD on breast cance...

Yue Sui, Qingqing Liu, Cong Xu, Kumar Ganesan, Zhen Ye, Yan Li… in Cell Death & Disease (2024)

Article

Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain

Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer’s disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic...

Qing Yu, Fang Du, Irla Belli, Patricia A. Gomes… in Cell Death & Disease (2024)

Article

USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer

A hallmark of tumor cells, including bladder cancer (BLCA) cells, is metabolic reprogramming toward aerobic glycolysis (Warburg effect). The classical oncogene MYC, which is crucial in regulating glycolysis, i...

Mingxing Li, **gtian Yu, Lingao Ju, Ye**peng Wang, Wan **… in Cell Death & Disease (2024)

Article

FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression

Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER stress leads to cell apoptosis. Despite increasing research in this area, the underlying molecular mechanisms rem...

**g Ji, Aixin **g, Yuanyuan Ding, **nhui Ma, Qilan Qian… in Cell Death & Disease (2024)

Article

Calcium influx-induced lytic cell death disrupts skin immune homeostasis

Yingxue Du, **angbing Qi, Lei Zhang, Yong Yang, Ting Chen in Cell Discovery (2023)

Article

Mutual communication between radiosensitive and radioresistant esophageal cancer cells modulates their radiosensitivity

Radiotherapy is an important treatment modality for patients with esophageal cancer; however, the response to radiation varies among different tumor subpopulations due to tumor heterogeneity. Cancer cells that...

Congying **e, **ao Chen, Yueming Chen, **ngyue Wang, Jiwei Zuo… in Cell Death & Disease (2023)

Article

Correction: MELK promotes HCC carcinogenesis through modulating cuproptosis-related gene DLAT-mediated mitochondrial function

Zhipeng Li, Huaxin Zhou, **angyu Zhai, Lin Gao, Mengfan Yang… in Cell Death & Disease (2023)

Article

Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis

Numerous studies have proven the critical role of macrophages in the renal fibrosis process. Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play a ubiquito...

Lin **e, Ye Cheng, Wen Du, Lili Fu, Zhaonan Wei, Yuting Guan… in Cell Death & Disease (2023)