1 Result(s)

Article

PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation

The tumor suppressor phosphatase and tensin homolog (PTEN) dephosphorylates PIP3 and antagonizes the prosurvival PI3K-Akt pathway. Targeted deletion of PTEN in mice led to early embryonic lethality. To elucida...

Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong… in Cell Death & Differentiation (2015)