6 Result(s)
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Article
L Walker
Biomedicine
Oncology
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Article
Open AccessA multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours
This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibi...
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Article
Open AccessEvaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2
Single-nucleotide polymorphisms (SNPs) in genes involved in DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations in the high-risk susceptibility genes BRCA1 and BRCA2. The...
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Article
Open AccessLong-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial
The debate continues regarding the best management for women with low-grade abnormal cervical cytology attending colposcopy. We compared psychosocial outcomes of alternative management policies in these women.
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Article
Open AccessSwitching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women
We report an open-label, prospective, crossover study involving 184 post-menopausal women experiencing hot flushes on adjuvant tamoxifen (T). Six weeks after switching to an AI, the primary end point, hot flus...
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Article
Open AccessA prospective study of neurofibromatosis type 1 cancer incidence in the UK
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting around one in 3000 live births. The manifestations of this condition are extremely variable, even within families, and genetic counse...
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Article
Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients
According to the field cancerisation theory the entire upper aerodigestive tract has been mutagenised, thereby placing the affected individual at risk for the development of one or more cancers. To investigate...
