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  1. No Access

    Article

    CD4+FOXP3+ T regulatory cells decrease and CD3+CD8+ T cells recruitment in TILs from melanoma metastases after electrochemotherapy

    Electrochemotherapy (ECT) represents an effective local treatment for skin unresectable melanoma metastases with high overall objective response rate. ECT is based on the combination of anti-neoplastic drugs a...

    P. Di Gennaro, G. Gerlini, C. Urso, S. Sestini… in Clinical & Experimental Metastasis (2016)

  2. Article

    Open Access

    SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

    Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. We and others have previously shown that HEDGEHO...

    R Santini, S Pietrobono, S Pandolfi, V Montagnani, M D'Amico, J Y Penachioni… in Oncogene (2014)

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    Article

    WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function

    The Hedgehog-GLI (HH-GLI) signaling plays a critical role in controlling growth and tissue patterning during embryogenesis and is implicated in a variety of human malignancies, including those of the skin. Pho...

    S Pandolfi, V Montagnani, J Y Penachioni, M C Vinci, B Olivito, L Borgognoni… in Oncogene (2013)

  4. No Access

    Article

    Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells

    Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid which regulates multiple biological parameters in a number of cell types, including stem cells. Here we report, for the first time, that S1P dose-depen...

    P. Nincheri, P. Luciani, R. Squecco, C. Donati… in Cellular and Molecular Life Sciences (2009)