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Article
Open AccessLarge-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)
Large population-based cohort studies utilizing device-based measures of physical activity are crucial to close important research gaps regarding the potential protective effects of physical activity on chroni...
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Article
Open AccessThe R package for DICOM to brain imaging data structure conversion
The BIDSconvertR package is the first R-based tool for organizing magnetic resonance imaging (MRI) research data in accordance with the Brain Imaging Data Structure (BIDS) specification. Key features are the D...
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Article
Open AccessLongitudinal analyses of serum neurofilament light and associations with obesity indices and bioelectrical impedance parameters
Neurofilament light is a constituent of the neuronal cytoskeleton and released into the blood following neuro-axonal damage. It has previously been reported that NfL measured in blood serum is inversely relate...
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Article
Open AccessExploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity
The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general po...
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Article
Open AccessTranslation of mouse model to human gives insights into periodontitis etiology
To suggest candidate genes involved in periodontitis, we combined gene expression data of periodontal biopsies from Collaborative Cross (CC) mouse lines, with previous reported quantitative trait loci (QTL) in...
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Article
Open AccessFactors associated with habitual time spent in different physical activity intensities using multiday accelerometry
To investigate factors associated with time in physical activity intensities, we assessed physical activity of 249 men and women (mean age 51.3 years) by 7-day 24h-accelerometry (ActiGraph GT3X+). Triaxial vec...
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Article
Open AccessGenome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus
Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery s...
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Article
Genome-wide association study identifies 74 loci associated with educational attainment
A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational ...