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Numerical Comparison of Nasal Aerosol Administration Systems for Efficient Nose-to-Brain Drug Delivery

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  1. Article

    Open Access

    Nasal Irrigation Delivery in Three Post-FESS Models From a Squeeze-bottle Using CFD

    Nasal saline irrigation is highly recommended in patients following functional endoscopic sinus surgery (FESS) to aid the postoperative recovery. Post-FESS patients have significantly altered anatomy leading t...

    Hana Salati, Narinder Singh, Mehrdad Khamooshi, Sara Vahaji in Pharmaceutical Research (2022)

  2. Article

    Open Access

    Comparison of Sinus Deposition from an Aqueous Nasal Spray and Pressurised MDI in a Post-Endoscopic Sinus Surgery Nasal Replica

    Optimising intranasal distribution and retention of topical therapy is essential for effectively managing patients with chronic rhinosinusitis, including those that have had functional endoscopic sinus surgery...

    Joey Siu, James van Strien, Rosa Campbell, Paul Roberts in Pharmaceutical Research (2022)

  3. Article

    Open Access

    Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory

    Nose-to-brain transport of airborne ultrafine particles (UFPs) via the olfactory pathway has been verified as a possible route for particle translocation into the brain. The exact relationship between increase...

    Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen in Particle and Fibre Toxicology (2019)

  4. Article

    Open Access

    A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop

    Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of develo** respiratory, cardiovascular, and neurological disorders. Based on animal inhalation stud...

    Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen in Particle and Fibre Toxicology (2017)