![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
1,487 Result(s)
-
Article
Acceleration of brain tubulin formation in the optic lobe of the chick embryo by light stimulation
The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacryamide gel electrophoresis and computerized q...
-
Article
Anoxic block of GABAergic IPSPs
In rat hippocampal slices GABAergic IPSPs are very rapidly suppressed by anoxia (in<2 min). Both early (GABAA) and late (GABAB) components are affected. After reoxygenation, the IPSPs recover, but only slowly and...
-
Article
Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-l-arginine methyl ester
We studied the dose-response characteristics and the temporal profile of inhibition of brain nitric oxide (NO) synthase (NOS) elicited by i.v. administration of the NOS inhibitor nitro-l-arginine methyl ester (L-...
-
Article
Increased locus coeruleus glutamate levels are associated with naloxone-precipitate withdrawal from butorphanol in the rat
Extracellular fluid levels of glutamate were measured in the locus coeruleus during butorphanol (a mixed agonist at μ-, δ-, and κ-opioid receptors) withdrawal by using microdialysis in conscious butorphanol-de...
-
Article
Regulation of FFA by the acyltransferase pathway in focal cerebral ischemia-reperfusion
Cerebral insult is associated with a rapid increase in free fatty acids (FFA) and arachidonic acid release has been linked to the increase in eicosanoid biosynthesis. In transient focal cerebral ischemia induc...
-
Article
In utero hypoxic ischemia decreases the cholinergic agonist-stimulated poly-phosphoinositide turnover in the develo** rat brain
Perinatal hypoxic-ischemic (HI) insult is known to cause cellular and molecular disturbances leading to functional and behavioral abnormalities during brain development. In this study, we examined the effects ...
-
Article
μ- and δ-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence
The relative involvement of μ- and δ-opioid receptors in the mediation of butorphanol-, as compared to morphine-, dependence was examined with the use of highly selective antagonists at μ- and δ-opioid recepto...
-
Article
Uptake and distribution of fluorescein-labeled D2 dopamine receptor antisense oligodeoxynucleotide in mouse brain
To determine the uptake and distribution of oligodeoxynucleotides in brain, a 20-mer phosphorothioated oligodeoxynucleotide complementary to a portion of the D2 dopamine receptor mRNA was fluorescently labeled wi...
-
Article
Expression of carbonic anhydrase II mRNA and protein in oligodendrocytes during toxic demyelination in the young adult mouse
The aim of this study was to identify events that might take place in oligodendrocytes early in the process of demyelination, i.e., before the occurrence of massive loss of myelin. It was considered important ...
-
Article
Effects of Interferon and PKC Modulators on Human Glioma Protein Kinase C, Cell Proliferation, and Cell Cycle
The in-vitro effects of human interferon α-2b (HuIFN α-2b), protein kinase C (PKC) agonist [TPA (12-0-tetra-decanoyl-phorbol-13-acetate)] and PKC inhibitor (calphostin C) on human glioma (U-373MG) PKC activity...
-
Article
Lipid-Dependent Modulation of Ca2+ Availability in Isolated Mossy Fiber Nerve Endings
An enhancement of glutamate release from hippocampal neurons has been implicated in long-term potentiation, which is thought to be a cellular correlate of learning and memory. This phenomenom appears to be inv...
-
Article
Activation of JNK/SAPK in Primary Glial Cultures: II. Differential Activation of Kinase Isoforms Corresponds to Their Differential Expression
Recently, we reported on the activation of c-Jun N-terminal kinase (JNK) in primary glial cells noting certain differences in the patterns of kinase activation in astrocytes and oligodendrocytes (Zhang et al., J ...
-
Article
Effects of Ischemic Tolerance on mRNA Levels of IP3R1, β-Actin, and Neuron-Specific Enolase in Hippocampal CA1 Area of the Gerbil Brain
Global cerebral ischemia induced to Mongolian gerbils by ligation of common carotid arteries (CCAs) is known to result in injury to the hippocampal CA1 region. In this study, we examined whether neuronal injur...
-
Article
Evidence That Oxidized Proteins are Substrates for N-Terminal Arginylation
While the posttranslational N-terminal arginylation of proteins has been demonstrated in a variety of eukaryotic cells including neurons and their axons, the targets of the reaction are poorly understood. Seve...
-
Article
Rhizomelic Chondrodysplasia Punctata, a Peroxisomal Biogenesis Disorder Caused by Defects in Pex7p, a Peroxisomal Protein Import Receptor: A Minireview
Rhizomelic chondrodysplasia punctata (RCDP) is a lethal autosomal recessive disease correspondingto complementation group 11 (CG 11), the second most common of the thirteen CGs of peroxisomalbiogenesis disorde...
-
Article
Proportions of Ca2+ Channel Subtypes in Chick or Rat P2 Fraction and NG108-15 Cells Using Various Ca2+ Blockers
The proportions of calcium (Ca2+) channel subtypes in chick or rat P2 fraction and NG 108-15 cells were investigated using selective L-, N-, P- and P/Q- type Ca2+ channel blockers. KCl-stimulated 45Ca2+ uptake by...
-
Article
What Is the Signal for the Posttranslational Arginylation of Proteins?
The N-terminal, posttranslational arginylation of proteins is ubiquitous in eukaryotic cells. Previous experiments, using purified components of the reaction incubated in the presence of exogenous substrates, ...
-
Article
A New Subdivision, Marginal Division, in the Neostriatum of the Monkey Brain
A new subdivision, the “marginal division” (MrD), was discovered at the caudal border of the striatum and surrounds the rostral edge of the globus pallidus in the rat brain in our previous studies. The neurona...
-
Article
Calcium/Calmodulin Inhibits the Binding of Specific [125I]Omega-Conotoxin GVIA to Chick Brain Membranes
The effect of Ca2+/calmodulin (CaM) on the specific binding of [125I]omega-conotoxin GVIA (125I-ω-CTX) to crude membranes from chick brain was investigated. When we examined the effects of the activation of vario...
-
Article
Urologic status of 74 spinal cord injury patients from the 1976 Tangshan earthquake, and managed for over 20 years using the Credé maneuver
Objective: To evaluate the urologic safety of long-term Credé maneuver as bladder management in spinal cord injured patients.