3 Result(s)

Article

Publisher Correction: SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests

Wei Zhou, Wenjian Bi, Zhangchen Zhao, Kushal K. Dey… in Nature Genetics (2022)

Article

SAIGE-GENE+ improves the efficiency and accuracy of set-based rare variant association tests

Several biobanks, including UK Biobank (UKBB), are generating large-scale sequencing data. An existing method, SAIGE-GENE, performs well when testing variants with minor allele frequency (MAF) ≤ 1%, but inflat...

Wei Zhou, Wenjian Bi, Zhangchen Zhao, Kushal K. Dey… in Nature Genetics (2022)

Article

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics

Genome-wide association studies provide a powerful means of identifying loci and genes contributing to disease, but in many cases, the related cell types/states through which genes confer disease risk remain u...

Karthik A. Jagadeesh, Kushal K. Dey, Daniel T. Montoro, Rahul Mohan… in Nature Genetics (2022)