5 Result(s)
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Article
Karl E. Griswold
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Article
Open AccessEvolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally...
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Discovery of novel S. aureus autolysins and molecular engineering to enhance bacteriolytic activity
Staphylococcus aureus is a dangerous bacterial pathogen whose clinical impact has been amplified by the emergence and rapid spread of antibiotic resistance. In the search for more effecti...
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Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate
Biotherapeutics are subject to immune surveillance within the body, and anti-biotherapeutic immune responses can compromise drug efficacy and patient safety. Initial development of targeted antidrug immune me...
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Open AccessOptimization algorithms for functional deimmunization of therapeutic proteins
To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface di...
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Open AccessQuantifying and resolving multiple vector transformants in S. cerevisiae plasmid libraries
In addition to providing the molecular machinery for transcription and translation, recombinant microbial expression hosts maintain the critical genotype-phenotype link that is essential for high throughput sc...
