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  1. No Access

    Article

    High prevalence of theNBN gene mutation c.657-661del5 in Southeast Germany

    Nijmegen breakage syndrome (NBS), a rare autosomal recessive chromosomal instability disorder, is caused by mutations in theNBN gene. Most patients known so far are of Slavic origin and carry the major founder mu...

    M. Maurer, K. Hoffmann, K. Sperling, R. Varon in Journal of Applied Genetics (2010)

  2. No Access

    Article

    X chromosome painting in Microtus: Origin and evolution of the giant sex chromosomes

    Sex chromosomes in species of the genus Microtus present some characteristic features that make them a very interesting group to study sex chromosome composition and evolution. M. cabrerae and M. agrestis have en...

    J. A. Marchal, M. J. Acosta, H. Nietzel, K. Sperling, M. Bullejos… in Chromosome Research (2004)

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    Article

    Proving the Authenticity of Ancient DNA by Comparative Genomic Hybridization

     In PCR-supported amplification of ancient, degraded DNA, contamination with contemporary DNA can lead to false-positive results, which frequently give rise to discussions in which the mere existence of ancien...

    S. Hummel, B. Herrmann, J. Rameckers, D. Müller, K. Sperling… in Naturwissenschaften (1999)

  4. No Access

    Article

    Description of a chromosome replication unit in individual prematurely condensed human S-phase chromosomes

    Mammalian chromosome replication was studied by the aid of premature chromosome condensation (PCC). After induction of PCC the sites of DNA replication appear as “gaps” between condensed chromosomal regions. T...

    H. Hameister, K. Sperling in Chromosoma (1984)

  5. No Access

    Article

    Evolution of muntjac DNA

    The extent of nuclear single-copy DNA divergence between Muntiacus reevesi and Muntiacus muntjak vaginalis (Cervidae), a species pair showing extreme karyotype differences but striking morphological similarity, i...

    J. Schmidtke, H. Brennecke, M. Schmid, H. Neitzel, K. Sperling in Chromosoma (1981)

  6. No Access

    Article

    Arrangement of prematurely condensed chromosomes in cultured cells and lymphocytes of the Indian muntjac

    Premature chromosome condensation (PCC) was induced in order to study the arrangement of muntjac chromosomes in the interphase nuclei of proliferating and resting cells with respect to their polarity and the s...

    K. Sperling, E. -K. Lüdtke in Chromosoma (1981)

  7. No Access

    Article

    A simple staining technique to demonstrate chromosomal DNA replication

    With the BrdU technique here described, Giemsa stained metaphases with either early or late, replicational patterns can be obtained within 1 day after cell harvesting, showing a better resolution than3H-thymidine...

    R. -D. Wegner, K. Sperling in Experientia (1976)