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    Open Access

    Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

    Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular path...

    Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong… in Nature Communications (2020)

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    XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

    This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 p...

    ** Chen, Dimitrios Iliopoulos, Qing Zhang, Qianzi Tang, Matthew B. Greenblatt… in Nature (2014)