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  1. Article

    Open Access

    Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma

    Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor t...

    Jasper Wouters, Miguel Vizoso, Anna Martinez-Cardus, F. Javier Carmona… in BMC Medicine (2017)

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    Article

    Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

    The Wiskott-Aldrich syndrome protein (WASP; encoded by the gene WAS) and its homologs are important regulators of the actin cytoskeleton, mediating communication between Rho-family GTPases and the actin nucleatio...

    Koenraad Devriendt, Annette S. Kim, Gert Mathijs, Suzanna G.M. Frints… in Nature Genetics (2001)

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    Article

    Practical suggestions for successful immunoenzyme double-staining experiments

    Many methodologies exist to perform an immunoenzyme double staining. Hence, the practical problem arises as to which of these methods is optimal for one's own experimental design. A process of selection is des...

    Chris M. van der Loos, Anton E. Becker, Joost J. van den Oord in The Histochemical Journal (1993)