17 Result(s)

Article

Molecular genetic and immunotherapeutic targets in metastatic melanoma

In recent years, melanoma treatment has radically changed with the emergence of targeted therapies and immunotherapies. Both have led to improved survival for patients with advanced or unresectable melanoma. T...

C. Melis, A. Rogiers, O. Bechter, Joost J. van den Oord in Virchows Archiv (2017)

Article

Immunoplasticity in cutaneous melanoma: beyond pure morphology

Francesca Maria Bosisio, Joost J. van den Oord in Virchows Archiv (2017)

Article

Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients

Cutaneous melanoma is the most aggressive form of skin cancer. With age as a risk factor, melanoma is projected to become a substantial healthcare burden. The clinical course of melanoma in older patients is d...

Aljosja Rogiers, Joost J. van den Oord, Marjan Garmyn, Marguerite Stas… in Drugs & Aging (2015)

Article

Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression

Loss of E-cadherin expression in melanoma correlates with increased tumor thickness and reduced disease-free survival. The molecular mechanisms underpinning its differential expression in melanoma tissue remai...

Léon C. van Kempen, Karin van den Hurk, Vladimir Lazar, Stefan Michiels… in Virchows Archiv (2012)

Article

Tight skin and limited joint movements as early presentation of Hutchinson-Gilford progeria in a 7-week-old infant

We present a 7-week-old male infant with pseudoscleroderma as a primary manifestation of the Hutchinson-Gilford syndrome of premature aging. He had suffered intra-uterine growth retardation; micrognathism and ...

Lieve Sevenants, Carine Wouters… in European Journal of Pediatrics (2005)

Article

Immunophenotype and possible origin of nevi with phenotypical heterogeneity

Biphenotypical nevi or nevi with phenotypical heterogeneity consist of phenotypically different cell populations in a pattern other than that observed in classical combined nevi or in various maturation stages...

Véronique Winnepenninckx, Joost J. van den Oord in Archives of Dermatological Research (2004)

Article

Expression of the endothelin-B receptor in pigment cell lesions of the skin

Endothelins (ETs) exert several functions in human melanocytes, including proliferation, dendrite formation, and melanin synthesis. Among the ET receptors, the non-selective endothelin-B (ETB) receptor is the...

Anouk Demunter, Chris De Wolf-Peeters, Hugo Degreef, Marguerite Stas… in Virchows Archiv (2001)

Article

Binding of rabbit immunoglobulins to melanoma cells: a pitfall in the immunohistochemical study of malignant melanoma

Joost J. van den Oord, Jan Delabie in Virchows Archiv (2001)

Article

Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia

The Wiskott-Aldrich syndrome protein (WASP; encoded by the gene WAS) and its homologs are important regulators of the actin cytoskeleton, mediating communication between Rho-family GTPases and the actin nucleatio...

Koenraad Devriendt, Annette S. Kim, Gert Mathijs, Suzanna G.M. Frints… in Nature Genetics (2001)

Article

Small, freshly arrived histiocytes in cutaneous and mucosal herpetic lesions

We report on the predominance of a special type of small histiocyte in the inflammatory infiltrate accompanying herpetic bullae. These histiocytes, which have previously been taken to be neutrophils, are fresh...

Joost J. van den Oord, Rita De Vos… in Archives of Dermatological Research (1996)

Article

Physiological consequences of loss of plasminogen activator gene function in mice

Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactiva...

Peter Carmeliet, Luc Schoonjans, Lena Kieckens, Beverly Ream, Jay Degen… in Nature (1994)

Article

Practical suggestions for successful immunoenzyme double-staining experiments

Many methodologies exist to perform an immunoenzyme double staining. Hence, the practical problem arises as to which of these methods is optimal for one's own experimental design. A process of selection is des...

Chris M. van der Loos, Anton E. Becker, Joost J. van den Oord in The Histochemical Journal (1993)

Article

Localization of the cytoadhesin integrins in the human cornea

Cell-matrix interactions play a fundamental role in normal and pathological conditions. They can be mediated by the cytoadhesin subgroup of the integrin superfamily of adhesion molecules. Its members include t...

Brigitte Lauweryns, Joost J. van den Oord… in Graefe's Archive for Clinical and Experime… (1992)

Article

Lectin binding to human corneal endothelium

Beatrijs J. J. Foets, Joost J. van den Oord in Graefe's Archive for Clinical and Experime… (1991)

Article

Immunopathological study of vernal keratoconjunctivitis

The in situ immune reaction occurring in the conjunctival tissues of patients with vernal keratoconjunctivitis was studied using immunohistochemical techniques and a panel of monoclonal and polyclonal antibodi...

Ahmed M. Abu El-Asrar, Joost J. Van den Oord… in Graefe's Archive for Clinical and Experime… (1989)