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    Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks

    Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care products due to their broad-spectrum antibacterial and antifun...

    Jung Dae Lee, **-Sook Bae, Hyang Yeon Kim, Si-Whan Song in Archives of Toxicology (2024)

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    Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system

    This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thy...

    Je-Oh Lim, Je-Won Ko, Na-Rae Shin, Tae-Yang Jung, Changjong Moon in Archives of Toxicology (2019)

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    Role of Klotho, an antiaging protein, in pulmonary fibrosis

    Klotho is a recently discovered antiaging protein. Although many researchers are investigating the roles of Klotho in chronic kidney diseases and cancer, however, there are no studies on the roles of Klotho in...

    In-Sik Shin, Hyeun-Kyoo Shin, Jong-Choon Kim, Mee-Young Lee in Archives of Toxicology (2015)

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    Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats

    The present study investigated the protective effects of melatonin (MT) against gentamicin (GM)-induced nephrotoxicity and oxidative stress in rats. We also investigated the effects of MT on induction of apopt...

    In-Chul Lee, Sung-Hwan Kim, Sang-Min Lee, Hyung-Seon Baek in Archives of Toxicology (2012)

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    Embryo lethality and teratogenicity of a new fluoroquinolone antibacterial DW-116 in rats

    DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to i...

    Jong-Choon Kim, Hyo-In Yun, Ho-Chul Shin, Sang-Seop Han in Archives of Toxicology (2000)