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  1. No Access

    Article

    Mutation induction and inactivation in mammalian cells exposed to ionising radiation

    MAMMALIAN cell cultures are used to estimate mutation induction by radiation and chemical agents in the belief that they will provide relevant data for assessing risk to man and insights into the mechanisms of...

    JOHN THACKER, ROGER Cox in Nature (1975)

  2. No Access

    Article

    Mutation and inactivation of mammalian cells by various ionising radiations

    THERE is almost no information on the mutagenic effectiveness of the various ionising radiations for man and only limited information about radiations other than X or γ rays for experimental mammals. We have meas...

    ROGER Cox, JOHN THACKER, D. T. GOODHEAD, R. J. MUNSON in Nature (1977)

  3. No Access

    Article

    Non-rejoining DNA breaks and cell inactivation

    DUDLEY T. GOODHEAD, JOHN THACKER, ROGER COX in Nature (1978)

  4. No Access

    Article

    Fingerprinting cell lines: Use of human hypervariable DNA probes to characterize mammalian cell cultures

    Hypervariable DNA sequences may be used as probes to derive DNA “fingerprints” for individuals. To assess the use of the human 33.15 and 33.6 probes (isolated by Jeffreys and coworkers) for characterizing cell.....

    John Thacker, Michael B. T. Webb, Paul G. Debenham in Somatic Cell and Molecular Genetics (1988)

  5. No Access

    Article

    Analysis of large deletions in theHPRT gene of primary human fibroblasts using the polymerase chain reaction

    Spontaneous and X-ray-induced mutants of theHPRT gene were isolated from two primary human fibroblast lines. The limited life-span of the mutants restricted the use of methods requiring large quantities of DNA, a...

    Tracy Morris, Walter Masson, Belinda Singleton… in Somatic Cell and Molecular Genetics (1993)

  6. No Access

    Article

    The effectiveness of restriction endonucleases in cell killing and mutation

    The use of restriction endonucleases (RE) to study the importance of DNA break end structures in differential cellular response has proved controversial. The number of DNA cut sites and the accessibility of RE...

    Nina D. Costa, Walter K. Masson, John Thacker in Somatic Cell and Molecular Genetics (1993)

  7. No Access

    Article

    Mutations induced by DNA double-strand breaks: The influence of genomic site

    The transgenic CHO cell line PL61, carrying a recombinant SV40-gpt gene, was treated with restriction endonucleases to assess mutagenesis from defined DNA double-strand breaks. Mutations ingpt were measured under...

    Nina D. Costa, John Thacker in Somatic Cell and Molecular Genetics (1996)

  8. No Access

    Article

    Chromosomal aberrations induced by defined DNA double-strand breaks: The origin of achromatic lesions

    The mechanisms of formation of chromosomal aberrations are poorly understood, despite the common use of aberrations as a measure of the genetic effects of physical and chemical agents. We have used restriction...

    Alison N. Harvey, Nina D. Costa, John R. K. Savage… in Somatic Cell and Molecular Genetics (1997)

  9. No Access

    Article

    Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation

    Growth and development are dependent on the faithful duplication of cells. Duplication requires accurate genome replication, the repair of any DNA damage, and the precise segregation of chromosomes at mitosis;...

    Carol S. Griffin, Paul J. Simpson, Caroline R. Wilson, John Thacker in Nature Cell Biology (2000)

  10. No Access

    Article

    Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

    The radiosensitizing effect of caffeine has been associated with the disruption of multiple DNA damage-responsive cell cycle checkpoints, but several lines of evidence also implicate inhibition of DNA repair. ...

    Nesrin A Asaad, Zhao-Chong Zeng, Jun Guan, John Thacker, George Iliakis in Oncogene (2000)

  11. No Access

    Article

    Genetic interactions between RAD51 and its paralogues for centrosome fragmentation and ploidy control, independently of the sensitivity to genotoxic stresses

    We evaluate here whether RAD51 and its paralogues XRCC2 and XRCC3 act via a common pathway for sensitivity to genotoxic stress, centrosome fragmentation and chromosome stability. We expressed the RAD51 dominan...

    Fayza Daboussi, John Thacker, Bernard S Lopez in Oncogene (2005)

  12. No Access

    Article

    Exploring the Neighborhood-Level Impact of Retail Marijuana Outlets on Crime in Washington State

    Since 2012, the production, sale, and use of marijuana and its derivatives for recreational consumption have been legalized in 15 states and Washington, DC, but remain controversial nationwide. Critics argue t...

    John Thacker, Maggie Elliott Martin, Yvonne Cristy… in Journal of Quantitative Criminology (2023)