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  1. No Access

    Article

    Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma

    Adenocarcinomas show a stepwise progression from atypical adenomatous hyperplasia (AAH) through adenocarcinoma in situ (AIS) to invasive adenocarcinoma (IA). Immunoglobulin superfamily containing leucine-rich ...

    Toru Kimura, Takashi Akazawa, Yu Mizote in International Journal of Clinical Oncology (2024)

  2. Article

    Open Access

    Clinical outcomes of left upper segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide database study in Japan

    Given that left upper lobe and right upper and middle lobes share a similar anatomy, segmentectomy, such as upper division and lingulectomy, should yield identical oncological clearance to left upper lobectomy...

    Shinya Tane, Jiro Okami, Yoshimasa Maniwa, Yasushi Shintani, Hiroyuki Ito in Surgery Today (2024)

  3. No Access

    Article

    Metastatic pathways to the lower zone by segment in patients with clinical T1 lower lobe non-small cell lung cancer

    Segmentectomy and mediastinal lymph node dissection (LND) may increasingly be used for non-small cell lung cancer (NSCLC). Lymph node metastasis (LNM) distribution varies by lower lobe segments; however, its s...

    Tomohiro Maniwa, Masayuki Ohue, Ryu Kanzaki in General Thoracic and Cardiovascular Surgery (2024)

  4. Article

    Open Access

    Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer

    As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter...

    Yudai Miyashita, Naoko Ose, Jiro Okami, Koji Takami, Yasushi Sakamaki in Surgery Today (2023)

  5. No Access

    Article

    Non-adjacent interlobar lymph node metastasis distant from small-sized peripheral non-small cell lung cancer

    The optimal extent of lymph node dissection (LND) during segmentectomy is unclear. During segmentectomy, it is more challenging to dissect the non-adjacent interlobar lymph node (non-aiLN) away from the primar...

    Tomohiro Maniwa, Toru Kimura, Masayuki Ohue, Yasushi Shintani, Jiro Okami in Surgery Today (2022)

  6. No Access

    Article

    Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma

    Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this p...

    Akiisa Omura, Toru Kimura, Ryo Tanaka in General Thoracic and Cardiovascular Surgery (2022)

  7. No Access

    Article

    Mediastinal lymph node dissection in older patients with non-small cell lung cancer

    We evaluated the impact of omitting mediastinal lymph node dissection (MLND) from the surgical treatment of non-small cell lung cancer (NSCLC) in older patients.

    Tomohiro Maniwa, Toru Kimura, Masayuki Ohue, Jiro Okami in Surgery Today (2022)

  8. Article

    Open Access

    Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer

    AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama in BMC Cancer (2020)

  9. No Access

    Article

    Pleural recurrence after surgery for pleomorphic adenoma arising from peripheral lung: computed tomography-guided percutaneous needle biopsy as a possible mechanism of local failure

    A 75-year-old male was referred to our hospital because of an abnormal shadow found in the right lung 2 years prior that had been increasing in size. Chest computed tomography showed a 1-cm well-defined nodule...

    Toshiteru Tokunaga, Hidenori Kunou in General Thoracic and Cardiovascular Surgery (2015)

  10. No Access

    Article

    Pulmonary metastasectomy: outcomes and issues according to the type of surgical resection

    According to a recent report by the Committee for Scientific Affairs of the Japanese Association for Thoracic Surgery, pulmonary metastasectomy accounted for as many as 10.2 % of all entry cases of general tho...

    Masahiko Higashiyama, Toshiteru Tokunaga in General Thoracic and Cardiovascular Surgery (2015)

  11. No Access

    Article

    A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients

    Lung cancer patients with interstitial lung diseases (ILDs) who have undergone pulmonary resection often develop acute exacerbation of interstitial pneumonia (AE) in the post-operative period. To predict who i...

    Toshihiko Sato, Haruhiko Kondo in General Thoracic and Cardiovascular Surgery (2015)

  12. No Access

    Article

    Prognosis associated with surgery for non-small cell lung cancer and synchronous brain metastasis

    Several reports have described extended survival after aggressive surgical treatment for non-small cell lung cancer (NSCLC) and synchronous brain metastasis. This retrospective analysis assesses the prognostic...

    Takashi Kanou, Jiro Okami, Toshiteru Tokunaga, Ayako Fujiwara in Surgery Today (2014)

  13. No Access

    Article

    A possible abscopal effect of post-irradiation immunotherapy in two patients with metastatic lung tumors

    As well as its local effects, radiotherapy leads to the delayed regression of distant non-irradiated lesions. These abscopal effects are most likely mediated by the innate immune system. Patient 1, a 74-year-o...

    Ken Kodama, Masahiko Higashiyama, Jiro Okami in International Cancer Conference Journal (2014)

  14. No Access

    Article

    Surgical management of primary intrathoracic goiters

    Intrathoracic goiters account for 3.1%–5.8% of all mediastinal masses. Primary intrathoracic goiters, which receive their blood supply from mediastinal vessels and disconnect at the cervical thyroid, are even ...

    Ryu Kanzaki, Masahiko Higashiyama in General Thoracic and Cardiovascular Surgery (2012)

  15. No Access

    Article

    Surgical treatment for gastrointestinal metastasis of non-small-cell lung cancer after pulmonary resection

    Gastrointestinal metastasis is not common in recurrent non-small-cell lung cancer (NSCLC) patients. There is thus limited information on clinical outcome for these patients. This report presents the clinical c...

    Ayako Fujiwara, Jiro Okami in General Thoracic and Cardiovascular Surgery (2011)

  16. No Access

    Article

    Surgical resection of pulmonary metastases from meningioma: Report of a case

    Meningiomas rarely metastasize, and little information on pulmonary metastasectomy from meningioma has been documented. We herein report a case of a potentially curative resection for meningioma that metastasi...

    Ryu Kanzaki, Masahiko Higashiyama, Ayako Fujiwara, Toshiteru Tokunaga in Surgery Today (2011)

  17. Article

    Open Access

    Malignant pleural mesothelioma with long-term tumor disappearance of a local relapse after surgery: a case report

    There have been few reports of spontaneous regression of malignant pleural mesothelioma, but the mechanism for this is unknown. We present a case report on a patient with malignant pleural mesothelioma showing...

    Masahiko Higashiyama, Kazuyuki Oda, Jiro Okami in Journal of Medical Case Reports (2009)

  18. No Access

    Article

    Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: A case-control study

    We investigated whether adjuvant immunotherapy with Bacillus Calmette-Guérin (BCG) cell wall skeleton (CWS) and surgical resection was better than resection, with or without other adjuvant therapy, for patient...

    Ken Kodama, Masahiko Higashiyama, Koji Takami, Kazuyuki Oda, Jiro Okami in Surgery Today (2009)

  19. No Access

    Article

    Surgical treatment for lung cancer in the left lung complicated by isolated right thoracic isomerism

    The term “isolated right thoracic isomerism” is used to describe a situation in which the anatomy of the bronchi, lung lobes, and pulmonary vessels on the left side is similar to that on the right side with no...

    Ryu Kanzaki, Masahiko Higashiyama in General Thoracic and Cardiovascular Surgery (2008)

  20. No Access

    Article

    Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor

    Pancreatic cancer is characterized by invasive and metastatic potential. In this study, effects of the COX-2 inhibitor JTE-522 on cell viability, invasion, and invasion-related cellular properties were determi...

    Jiro Okami, Shoji Nakamori, Nobuaki Hiraoka in Clinical & Experimental Metastasis (2003)