-
Article
Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma
Adenocarcinomas show a stepwise progression from atypical adenomatous hyperplasia (AAH) through adenocarcinoma in situ (AIS) to invasive adenocarcinoma (IA). Immunoglobulin superfamily containing leucine-rich ...
-
Article
Open AccessClinical outcomes of left upper segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide database study in Japan
Given that left upper lobe and right upper and middle lobes share a similar anatomy, segmentectomy, such as upper division and lingulectomy, should yield identical oncological clearance to left upper lobectomy...
-
Article
Metastatic pathways to the lower zone by segment in patients with clinical T1 lower lobe non-small cell lung cancer
Segmentectomy and mediastinal lymph node dissection (LND) may increasingly be used for non-small cell lung cancer (NSCLC). Lymph node metastasis (LNM) distribution varies by lower lobe segments; however, its s...
-
Article
Open AccessOutcomes of surgical resection for pulmonary metastasis from pancreatic cancer
As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter...
-
Article
Non-adjacent interlobar lymph node metastasis distant from small-sized peripheral non-small cell lung cancer
The optimal extent of lymph node dissection (LND) during segmentectomy is unclear. During segmentectomy, it is more challenging to dissect the non-adjacent interlobar lymph node (non-aiLN) away from the primar...
-
Article
Surgical indication of pulmonary metastasis arising from osteosarcoma or soft tissue sarcoma
Metastasectomy is often the local treatment for pulmonary metastases arising from osteosarcoma or soft tissue sarcoma. However, there have been few investigations on the outcomes of patients who undergo this p...
-
Article
Mediastinal lymph node dissection in older patients with non-small cell lung cancer
We evaluated the impact of omitting mediastinal lymph node dissection (MLND) from the surgical treatment of non-small cell lung cancer (NSCLC) in older patients.
-
Article
Open AccessPreoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer
AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...
-
Article
Pleural recurrence after surgery for pleomorphic adenoma arising from peripheral lung: computed tomography-guided percutaneous needle biopsy as a possible mechanism of local failure
A 75-year-old male was referred to our hospital because of an abnormal shadow found in the right lung 2 years prior that had been increasing in size. Chest computed tomography showed a 1-cm well-defined nodule...
-
Article
Pulmonary metastasectomy: outcomes and issues according to the type of surgical resection
According to a recent report by the Committee for Scientific Affairs of the Japanese Association for Thoracic Surgery, pulmonary metastasectomy accounted for as many as 10.2 % of all entry cases of general tho...
-
Article
A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients
Lung cancer patients with interstitial lung diseases (ILDs) who have undergone pulmonary resection often develop acute exacerbation of interstitial pneumonia (AE) in the post-operative period. To predict who i...
-
Article
Prognosis associated with surgery for non-small cell lung cancer and synchronous brain metastasis
Several reports have described extended survival after aggressive surgical treatment for non-small cell lung cancer (NSCLC) and synchronous brain metastasis. This retrospective analysis assesses the prognostic...
-
Article
A possible abscopal effect of post-irradiation immunotherapy in two patients with metastatic lung tumors
As well as its local effects, radiotherapy leads to the delayed regression of distant non-irradiated lesions. These abscopal effects are most likely mediated by the innate immune system. Patient 1, a 74-year-o...
-
Article
Surgical management of primary intrathoracic goiters
Intrathoracic goiters account for 3.1%–5.8% of all mediastinal masses. Primary intrathoracic goiters, which receive their blood supply from mediastinal vessels and disconnect at the cervical thyroid, are even ...
-
Article
Surgical treatment for gastrointestinal metastasis of non-small-cell lung cancer after pulmonary resection
Gastrointestinal metastasis is not common in recurrent non-small-cell lung cancer (NSCLC) patients. There is thus limited information on clinical outcome for these patients. This report presents the clinical c...
-
Article
Surgical resection of pulmonary metastases from meningioma: Report of a case
Meningiomas rarely metastasize, and little information on pulmonary metastasectomy from meningioma has been documented. We herein report a case of a potentially curative resection for meningioma that metastasi...
-
Article
Open AccessMalignant pleural mesothelioma with long-term tumor disappearance of a local relapse after surgery: a case report
There have been few reports of spontaneous regression of malignant pleural mesothelioma, but the mechanism for this is unknown. We present a case report on a patient with malignant pleural mesothelioma showing...
-
Article
Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: A case-control study
We investigated whether adjuvant immunotherapy with Bacillus Calmette-Guérin (BCG) cell wall skeleton (CWS) and surgical resection was better than resection, with or without other adjuvant therapy, for patient...
-
Article
Surgical treatment for lung cancer in the left lung complicated by isolated right thoracic isomerism
The term “isolated right thoracic isomerism” is used to describe a situation in which the anatomy of the bronchi, lung lobes, and pulmonary vessels on the left side is similar to that on the right side with no...
-
Article
Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor
Pancreatic cancer is characterized by invasive and metastatic potential. In this study, effects of the COX-2 inhibitor JTE-522 on cell viability, invasion, and invasion-related cellular properties were determi...