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  1. No Access

    Article

    CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer’s disease

    Alzheimer’s disease (AD) is the most common form of neurodegenerative disease featured with memory loss and cognitive function impairments. Chronic mitochondrial stress is a vital pathogenic factor for AD and ...

    Wenting **e, Dong Guo, Jieyin Li, Lei Yue, Qi Kang… in Cell Death & Differentiation (2022)

  2. Article

    Open Access

    Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

    Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We her...

    Shourong Wang, Zixiang Wang, Jieyin Li, Junchao Qin, Jian** Song… in Cell Death & Disease (2021)

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  3. Article

    miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma

    Activation of mammalian target of rapamycin (mTOR) signaling pathway is associated with poor prognosis of epithelial ovarian cancer. The TSC1-TSC2 complex is a critical negative regulator of mTOR signaling. He...

    Yuqiong Wang, **yu Zhang, Wei Tang, Zhenghong Lin, Limei Xu… in Cell Death & Differentiation (2017)

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