12 Result(s)

Article

Analysis of risk factors for adjacent superior vertebral pedicle-induced facet joint violation during the minimally invasive surgery transforaminal lumbar interbody fusion: a retrospective study

The purpose was to explore possible risk factors of facet joint violation induced by adjacent superior vertebral pedicle screw during the minimally invasive surgery transforaminal lumbar interbody fusion (MIS-...

Zhi-Li Zeng, Long Jia, Wei Xu, Yan Yu, **ao Hu… in European Journal of Medical Research (2015)

Article

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

In tauopathies, memory impairment positively strongly correlates with the amount of abnormal tau aggregates; however, how tau accumulation induces synapse impairment is unclear. Recently, we found that human t...

**ao-Yue Hong, Hua-Li Wan, Ting Li… in Signal Transduction and Targeted Therapy (2020)

Article

A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies

Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders, collectively termed as tauopathies, including the most common Alzheimer’s disease...

Jie Zheng, Na Tian, Fei Liu, Yidian Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatmen...

Meng-Li Wu, Feng-Liang Liu, **g Sun, **n Li… in Signal Transduction and Targeted Therapy (2021)

Article

Recombinant human erythropoietin ameliorates cognitive dysfunction of APP/PS1 mice by attenuating neuron apoptosis via HSP90β

Hua-Li Wan, Bing-Ge Zhang, Chongyang Chen… in Signal Transduction and Targeted Therapy (2022)

Article

Lactate metabolism in human health and disease

The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis sugges...

**aolu Li, Yanyan Yang, Bei Zhang, **aotong Lin… in Signal Transduction and Targeted Therapy (2022)

Article

Correction: Lactate metabolism in human health and disease

**aolu Li, Yanyan Yang, Bei Zhang, **aotong Lin… in Signal Transduction and Targeted Therapy (2022)

Article

Carpets with visual cues can improve gait in Parkinson’s disease patients: may be independent of executive function

Gait impairment is common in Parkinson’s disease (PD) patients, which greatly reduces their quality of life. Executive dysfunction is associated with gait impairment. Compensatory strategies, including visual ...

Ze-Di Hu, Shi-Guo Zhu, Jie-Fan Huang, **-Yu Chen… in European Journal of Medical Research (2023)

Article

Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis

The objective of this study was to explore the associations of body mass index (BMI), fat mass index (FMI), skeletal mass index (SMI) and secondary osteoporosis (OP) in patients with rheumatoid arthritis (RA).

Yi-ran Chu, Yue-chen Xu, Ling-li Ma… in European Journal of Medical Research (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Association analyses of apolipoprotein E genotypes and cognitive performance in patients with Parkinson’s disease

Cognitive impairment is a common non-motor symptom of Parkinson’s disease (PD). The apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer’s disease (AD). However, the effect of APOEε4 on cognitiv...

Shi-Guo Zhu, Zhu-Ling Chen, Ke **ao, Zi-Wei Wang… in European Journal of Medical Research (2024)