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Hematology
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Article
Melanoma cells growing in aggregates on a non-adhesive poly(HEMA) substrate exhibit polykaryocytosis but do not develop an increased metastatic capability
B16-F1 melanoma cells were plated onto plastic tissue-culture dishes rendered non-adhesive for cells by coating with 0–12 per cent poly(2-hydroxyethyl methylacrylate), poly(HEMA). These growth conditions cause...
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In vitro modulation of the metastatic phenotype. I. Analysis of differentiation forms of the B16 melanoma expressing Met-72 determinants and metastatic activity
In vitro cultures of a highly metastatic B16 melanoma clone (BL6-10) were found to undergo dramatic changes in morphology and differentiation upon transfer to another culture medium. Specifically, BL6-10 melanom...
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Isolation of metastatic B16 melanoma variants using anti-Met 72 monoclonal antibodies and flow cytometry
Analysis of a number of B16 melanoma clones has revealed a high correlation between metastatic activity and the quantitative expression of a 72 000 dalton glycoprotein, Met 72. In the present study, metastatic...
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The lack of correlation between experimental metastatic potential and platelet aggregating activity of B16 melanoma clones viewed in relation to tumor cell heterogeneity
Two widely used B16 melanoma cell lines of low and high lung colonizing potential (B16-F1 and B16-F10) were compared in their ability to induce platelet aggregation. The results of these experiments showed a r...
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Synthesis and expression of metastasis-associated, Met-72/83 antigens
In the present study, we report a more detailed biochemical analysis of the B16 melanoma, metastasis-associated, Met-72 antigen. Specifically, we have examined (1) the molecular forms of Met-72 isolated during...
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Serum hormone levels in pre-menopausal Chinese women in Shanghai and white women in Los Angeles: results from two breast cancer case-control studies
To assess whether risk of breast cancer in young women is associated with differences in luteal-phase hormone production and to attempt to explain differences in risk of breast cancer of young Shanghai Chinese...
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Tobacco smoking, alcohol consumption, and risk of oral cancer: a case-control study in Bei**g, People's Republic of China
A case-control study of oral cancer was conducted in Bei**g, People's Republic of China (PRC). The study was hospital-based and controls were hospital in-patients matched for age and gender with the cases. Th...
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Dentition, oral hygiene, and risk of oral cancer: a case-control study in Bei**g, People's Republic of China
A case-control study of oral cancer was conducted in Bei**g, People's Republic of China. The study was hospitalbased and controls were hospital in-patients matched to the cases by age and gender. A total of 4...
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A research for the relationship between human papillomavirus and human uterine cervical carcinoma
Biopsies from 318 cases with squamous cell carcinoma of the uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 with nor...
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In vivo and in vitro mechanisms of cardiac allograft acceptance in the rat after short treatment with 15-deoxyspergualin
15-Deoxyspergualin (DSG) has been reported to be a useful immunosuppressive agent already used to inhibit acute rejection in clinical transplantation. In the present study, the survival of heart allograft in r...
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Analysis of prognostic factors affecting renal allograft survival
A total of 201 consecutive cadaveric kidney transplantations were performed in 188 patients at the Chinese Great Wall Hospital, Bei**g, from October 1977 to May 1990. The overall 1-, 2-, 5-, and 10-year graft...
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The role of cryosurgery in the treatment of hepatic cancer: a report of 113 cases
From November 1973 to June 1992, cryosurgery with liquid nitrogen (−196°C) was performed on 113 patients with hepatic cancer, including 107 patients with primary liver cancer (PLC) and 6 patients with secondar...
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Regulation of spreading and growth of colon cancer cells by hepatocyte growth factor
Hepatocyte growth factor (HGF), also known as scatter factor, regulates both cell motility and the growth of some cell types. We have determined the effects of HGF on the motility and growth of human colon can...
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Occupational risk factors for lung cancer among nonsmoking women: a case-control study in Missouri (United States)
Occupationally related risk of lung cancer among women and among nonsmokers has not been widely studied. A recently conducted population-based, case-control study in Missouri (United States) provided the oppor...
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Recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, by release from tumor burden
The present study investigates the recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, following release of tumor burden. Spleen cells from BALB/c mice bearing a syngeneic tum...
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The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival
In this present study, the effects of FK 506 and 15-deoxyspergualin (DSG), with respect to dose, timing, and combination, were investigated in an ACI-to-LEW rat cardiac allograft model. FK 506 was adminstered ...
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Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferon α gene therapy in combination with adoptive chemoimmunotherapy
The therapeutic effect of the fibroblast-mediated human interferon (IFNα) gene therapy in combination with interleukin-2 (IL-2) activated killer cells (AK)/doxorubicin (i.e., adoptive chemoimmunotherapy) on nu...
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Inhibition of cancer cell motility and invasion by interleukin-12
Tumour cell motility and attachment are crucial requirements in the formation of metastatic lesions. These properties are affected by a number of cytokines including hepatocyte growth factor/scatter factor (HG...
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mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential
Levels of expression of the nm23 gene inversely correlated with metastatic potential in several rodent tumor model systems and human breast carcinoma. In the present study, we examined nm23 mRNA levels in two ...
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Human hepatitis B virus and hepatocellular carcinoma II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1
On the basis of the successful establishment of an animal model in tree shrews experimentally infected with human hepatitis B virus (HBV), a study on the hepatocarcinogenic effects of HBV and/or aflatoxin B1 (...
