5 Result(s)
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Article
Jesse H. Erasmus
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A chikungunya fever vaccine utilizing an insect-specific virus platform
New vaccine approaches that safely elicit immunity are needed to protect against infectious disease. Erasmus et al. report their development of an insect-virus-based platform that they use to engineer a protectiv...
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Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics
The emergence and re-emergence of highly virulent viral pathogens with the potential to cause a pandemic creates an urgent need for the accelerated discovery of antiviral therapeutics. Antiviral human monoclon...
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Open AccessIntramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes
Single domain antibodies (sdAbs), also called nanobodies, have substantial biophysical advantages over conventional antibodies and are increasingly being employed as components of immunotherapeutic agents. One...
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Open AccessAccelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine
Malaria, caused by Plasmodium parasites, remains one of the most devastating infectious diseases worldwide, despite control efforts to lower morbidity and mortality. Both advanced candidate vaccines, RTS,S and R2...
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Open AccessA gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge
Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative disorders and is the causative agent of infectious mononucleosis. A vaccine that prevents EBV-driven morbidity and mortality ...
