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Open AccessPrognostic impact of absolute peripheral blood NK cell count after four cycles of R-CHOP-like regimen treatment in patients with diffuse large B cell lymphoma
As a subtype of lymphocyte, natural killer (NK) cell is the first line of defense that shows a strong function in tumor immunotherapy response and clinical outcomes. The current study aims to investigate the p...
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Article
Open AccessImmune-related lncRNAs pairs prognostic score model for prediction of survival in acute myeloid leukemia patients
Acute myeloid leukemia (AML) is one of the most common malignant and aggressive hematologic tumors, and risk stratification is indispensable to ensure proper treatment. But immune-related long noncoding RNAs (...
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Article
Open AccessSYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer
Genomic MET amplification and exon 14 skip** are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met in...
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Article
Open AccessEfficacy, Safety, Patient Experience, and Tolerability of Risankizumab Administered by On-Body Injector for Moderate to Severe Crohn’s Disease
In patients with moderate to severe Crohn’s disease (CD), intravenous induction and subcutaneous maintenance dosing with risankizumab was efficacious and well tolerated. Long-term management of CD via self-adm...
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Article
Open AccessIs serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
To assess whether serum thymidine kinase 1 (STK1p), CEA and CA19.9 can be used as prognostic biomarkers in the primary tumor location (PTL) of colorectal carcinoma (CRC). Additional clinical factors of TNM sta...
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Article
Open AccessSOX2 knockdown with siRNA reverses cisplatin resistance in NSCLC by regulating APE1 signaling
SOX2 is related to drug resistance in many types of cancer, including lung cancer. Herein, we investigated the role of SOX2 and its regulatory signaling in cisplatin-treated non-small-cell lung cancer (NSCLC)....
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Open AccessThe role of a multidisciplinary team in the management of portal hypertension
Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The current recommendations for gastroesophageal varices include pharmacological treatme...
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Article
HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas
To investigate the role of HIF-1α genetic polymorphism of c.1772C>T and c.1790G>A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched health...
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Article
Serum thymidine kinase 1 concentration as a prognostic factor of chemotherapy-treated non-Hodgkin’s lymphoma patients
This study was performed to examine possible use of thymidine kinase 1 concentration in serum (STK1) for prognosis of non-Hodgkin’s lymphoma patients following chemotherapy treatment.
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Article
Genetic diagnosis of multiple affected tissues in a patient with McCune–Albright syndrome
McCune–Albright syndrome (MAS) is a sporadic disorder characterized by the classic triad of polyostotic fibrous dysplasia, ‹café-au-lait’ skin pigmentation, and hyperfunctional endocrinopathy. It is caused by ...
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Article
Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion
To determine whether sulfasalazine can prevent apoptosis in spermatogenic cells by preventing the activation of NF-κB in spermatogenic epithelium in experimental testicular torsion.