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Tracing cancer networks with phosphoproteomics
A mass-spectrometry approach for identifying downstream events in cancer signaling pathways may help to tailor therapies to individual patients.
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Article
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Du et al. describe a bead-based method for high-throughput detection of phosphorylated tyrosine kinases and use it to profile 130 human cancer lines. They show that the tyrosine kinase SRC is frequently activated...