11 Result(s)

Article

Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R

Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors. Sulfatinib is a multi-target kinase inhibitor for treating neu...

Qianmeng Lin, Shuyan Dai, Lingzhi Qu, Hang Lin, Ming Guo… in Communications Chemistry (2024)

Article

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through d...

Hudie Wei, Haolan Wang, Genxin Wang, Lingzhi Qu, Longying Jiang… in Nature Communications (2023)

Article

Targeting p53 pathways: mechanisms, structures, and advances in therapy

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multi...

Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen in Signal Transduction and Targeted Therapy (2023)

Article

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor

The aryl hydrocarbon receptor (AHR), a member of the basic helix–loop–helix (bHLH) Per–Arnt–Sim (PAS) family of transcription factors, plays important roles in regulating xenobiotic metabolism, cellular differ...

Shuyan Dai, Lingzhi Qu, Jun Li, Ye Zhang, Longying Jiang… in Nature Communications (2022)

Article

Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants

Fibroblast growth factor receptor (FGFR) dysregulation is involved in a variety of tumorigenesis and development. Cholangiocarcinoma is closely related with FGFR aberrations, and pemigatinib is the first drug ...

Qianmeng Lin, **aojuan Chen, Lingzhi Qu, Ming Guo, Hudie Wei… in Communications Chemistry (2022)

Article

Author Correction: Structure-based design of a dual-warhead covalent inhibitor of FGFR4

**aojuan Chen, Huiliang Li, Qianmeng Lin, Shuyan Dai… in Communications Chemistry (2022)

Article

Structure-based design of a dual-warhead covalent inhibitor of FGFR4

The fibroblast growth factor 19 (FGF19)/fibroblast growth factor receptor 4 (FGFR4) signaling pathways play critical roles in a variety of cancers, such as hepatocellular carcinoma (HCC). FGFR4 is recognized a...

**aojuan Chen, Huiliang Li, Qianmeng Lin, Shuyan Dai… in Communications Chemistry (2022)

Article

Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors

FIIN-2, TAS-120 (Futibatinib) and PRN1371 are highly potent pan-FGFR covalent inhibitors targeting the p-loop cysteine of FGFR proteins, of which TAS-120 and PRN1371 are currently in clinical trials. It is cri...

Lingzhi Qu, **aojuan Chen, Hudie Wei, Ming Guo, Shuyan Dai… in Communications Chemistry (2022)

Article

Targeting MCL-1 in cancer: current status and perspectives

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor t...

Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen in Journal of Hematology & Oncology (2021)

Article

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by interacting with and antagonizing the anti-apoptotic ...

Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng… in Nature Communications (2021)

Article

Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade

The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly...

Fei Zhang, Hudie Wei, **aoxiao Wang, Yu Bai, Pilin Wang, Jiawei Wu… in Cell Discovery (2017)